81097-33-8Relevant academic research and scientific papers
Catalyst- and Reagent-Free Formal Aza-Wacker Cyclizations Enabled by Continuous-Flow Electrochemistry
Huang, Chong,Li, Zhao-Yu,Song, Jinshuai,Xu, Hai-Chao
, p. 11237 - 11241 (2021/04/09)
The development of efficient and sustainable methods to access saturated N-heterocycles is of great importance because of the prevalence of these structures in natural products and bioactive compounds. Pd-catalyzed aza-Wacker type cyclization is a powerful method and provides access to N-heterocycles bearing an alkene moiety available for further synthetic manipulations from readily available materials. Herein we disclose a catalyst- and reagent-free formal aza-Wacker type cyclization reaction for the synthesis of functionalized saturated N-heterocycles. Key to the success is to conduct the reactions in a continuous-flow electrochemical reactor without adding supporting electrolyte or additives. The reactions are characterized by broad tolerance of di-, tri- and tetrasubstituted alkenes.
Palladium-Catalyzed Cyclization of ω-Olefinic Tosamides. Synthesis of Nonaromatic Nitrogen Heterocycles
Hegedus, Louis S.,McKearin, James M.
, p. 2444 - 2451 (2007/10/02)
The cyclization of aliphatic amino olefins to nonaromatic nitrogen heterocycles nas been accomplished by conversion of the amine to the corresponding p-toluenesulfonamide, followed by Pd(II)-catalyzed intramolecular amination of the olefin.The resulting t
