81104-13-4Relevant academic research and scientific papers
Improving the fluorescent probe acridonylalanine through a combination of theory and experiment
Sungwienwong, Itthipol,Ferrie, John J.,Jun, Joomyung V.,Liu, Chunxiao,Barrett, Taylor M.,Hostetler, Zachary M.,Ieda, Naoya,Hendricks, Amara,Muthusamy, Anand K.,Kohli, Rahul M.,Chenoweth, David M.,Petersson, George A.,Petersson, E. James
supporting information, (2018/02/27)
Acridonylalanine (Acd) is a useful fluorophore for studying proteins by fluorescence spectroscopy, but it can potentially be improved by being made longer wavelength or brighter. Here, we report the synthesis of Acd core derivatives and their photophysical characterization. We also performed ab initio calculations of the absorption and emission spectra of Acd derivatives, which agree well with experimental measurements. The amino acid aminoacridonylalanine (Aad) was synthesized in forms appropriate for genetic incorporation and peptide synthesis. We show that Aad is a superior F?rster resonance energy transfer acceptor to Acd in a peptide cleavage assay and that Aad can be activated by an aminoacyl tRNA synthetase for genetic incorporation. Together, these results show that we can use computation to design enhanced Acd derivatives, which can be used in peptides and proteins.
Design, synthesis, antitumor evaluation, 3D-QSAR and molecular docking studies of novel 4-aminoacridone compounds
Tian, Lin,Feng, Chang J.,Li, Tong X.,Li, Zhao,Yang, Wei H.,Han, Xiang E.
, p. 2538 - 2546 (2017/10/03)
4-aminoacridone was efficiently synthesized using an optimized method and condensed with a variety of different aldehydes to give the corresponding Schiff bases, 1a–k. The antiproliferative activities of these compounds were measured against several human
Zn2+ mediated solvent free solid state red emitting fluorescent complex formation in a mortar-pestle along with living cell imaging studies
Adhikari, Susanta,Ghosh, Avijit,Mandal, Sandip,Sahana, Animesh,Das, Debasis
, p. 33878 - 33884 (2015/04/27)
An acridone based highly Zn2+ selective, cell-permeable turn-on fluorescence probe (AAS) shows yellow fluorescence at 560 nm (λex, 445 nm) in dry methanol/DMSO up to 100 μM Zn2+. At higher Zn2+ concentration (>1
NEUROLOGICALLY-ACTIVE COMPOUNDS
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Page 73, (2010/02/06)
The present invention relates to neurologically-active compounds, being heterocyclic compounds having two fused 6-membered rings with a nitrogen atom at position 1 and a hydroxy or mercapto group at position 8 with at least one ring being aromatic. Also disclosed are processes for the preparation of these compounds and their use as pharmaceutical or veterinary agents, in particular for the treatment of neurological conditions, more specifically neurodegenerative conditions such as Alzheimer's disease.
New sulphonamides with acridinic nucleus
Ferencz, László,Fǎrcǎ?an, Valer,Silberg, Ioan A.
, p. 801 - 811 (2007/10/03)
Twelve new sulphonamides with acridonic and acridinic nucleus were synthesized, in which the sulphonamidic group appears in positions 1, 2, 3 and 4. We also obtained the corresponding acridanes, but we did not isolate them. We proved that in the case of 2-nitroacridone synthesis, by ring closure of 4-nitrodiphenylamine-2-carboxylic acid, working in the presence of sulphuric acid, sulphonation takes place. To reduce some nitroacridones we used hydrazine hydrate in the presence of Ni from formiate and Ni Raney, a method not yet mentioned in the literature for compounds of this class, and which presents many advantages. We proved that sulphonamides with acridonic nucleus can be transformed into the corresponding acridines, by reduction with Na-amalgam. The studied new substances show a noteworthy activity against microorganisms.
Structure-trypanodical activity relationships
Bsiri,Johnson,Kayirere,Galy,Galy,Barbe,Osuna,Mesa-Valle,Castilla Calvente,Rodriguez-Cabezas
, p. 27 - 33 (2007/10/03)
A set of 9-thioalkylacridinones, has been prepared and investigated' in vitro' against T. cruzi. Structure-antiparasitic activity relationships are detailed with a view to identify the major structural parameters for the activity under consideration.
