81128-05-4Relevant academic research and scientific papers
Sulfinates from Amines: A Radical Approach to Alkyl Sulfonyl Derivatives via Donor-Acceptor Activation of Pyridinium Salts
Andrews, Jonathan A.,Pantaine, Lo?c R. E.,Palmer, Christopher F.,Poole, Darren L.,Willis, Michael C.
supporting information, p. 8488 - 8493 (2021/11/01)
Synthetically versatile alkyl sulfinates can be prepared from readily available amines, using Katritzky pyridinium salt intermediates. In a catalyst-free procedure, primary, secondary, and benzylic alkyl radicals are generated by photoinduced or thermally induced single-electron transfer (SET) from an electron donor-acceptor (EDA) complex, and trapped by SO2 to generate sulfonyl radicals. Hydrogen atom transfer (HAT) from Hantzsch ester gives alkyl sulfinate products, which are used to prepare a selection of medicinal chemistry relevant sulfonyl-containing motifs.
The Preparation of Pyridiniums from Pyryliums
Katritzky, Alan R.,Lloyd, Jeremy M.,Patel, Ranjan C.
, p. 117 - 124 (2007/10/02)
Mild preparative conditions are described for the reaction of primary alkyl-, secondary alkyl-, and aryl-primary amines (including weakly basic amines) with pyryliums (including those with bulky α-substituents).Conditions were optimized by 13C n.m.r. stud
