81133-69-9Relevant academic research and scientific papers
Efficient preparation of secondary aminoalcohols through a Ti(IV) reductive amination procedure. Application to the synthesis and antibacterial evaluation of new 3β-N-[hydroxyalkyl]aminosteroid derivatives
Salmi, Chanaz,Loncle, Céline,Letourneux, Yves,Brunel, Jean Michel
, p. 4453 - 4459 (2008/09/20)
An efficient method for the synthesis of various secondary aminoalcohols through a titanium(IV) isopropoxide-mediated reductive amination reaction of ketones is reported. Thus, different ketones gave the expected products in moderate to excellent yields up to 89% in numerous cases. A series of 3β-N-[hydroxyalkyl]aminosteroid derivatives were prepared according to this methodology and evaluated for their in vitro antimicrobial properties against human pathogens. All the compounds showed moderate to excellent activities against Gram-positive bacteria exhibiting similar results against Staphylococcus aureus and Streptococcus faecalis with Minimum Inhibitory Concentrations (MICs) varying from 3.12 to 25 μg/mL. No significant antibacterial activities are encountered against Gram-negative bacteria.
Reductive amination of carbonyl compounds via periodate oxidation of N-alkylethanolamine
Sreekumar R.,Pillai, R. B. C.,Pillai, C. N.
, p. 692 - 693 (2007/10/02)
Oxidation of N-alkylethanolamines (1) by periodate to obtain alkylamines (3) is reported.N-Alkylformamide is also formed during the oxidation.This is reported for the first time.Since compounds 1 are conveniently prepared by the reductive alkylation of ethanolamine by carbonyl compounds, the present reaction is an indirect troute for the amination of aldehydes and ketones with potential for application in asymmetric synthesis.
