81152-53-6Relevant academic research and scientific papers
Method for synthesizing 2-guanidinothiazole compound by one-pot process
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Paragraph 0014, (2020/11/09)
According to the invention, a substituted methyl ketone compound is innovatively used as a raw material, amidinothiourea is added into an alcohol solvent under the conditions of halogeno salt MX and Oxone, and a one-pot process one-step reaction is carried out to obtain the target 2-guanidinothiazole compound. Common methyl ketone is used for replacing an alpha-halogenated carbonyl compound whichis high in price and toxicity, MX which is low in price and easy to obtain is used as a halogen source, the method is novel, raw materials and reagents are cheap, reaction conditions are mild, and operation is easy and convenient, therefore low-cost, convenient and rapid synthesis of the 2-guanidinothiazole compound is achieved.
GUANIDINE DERIVATIVES OF IMIDAZOLES AND THIAZOLES
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, (2016/02/01)
The invention relates to guanidine derivatives of imidazoles and thiazoles which are histamine H-2 antagonists and which inhibit the secretion of gastric acid, to methods for their manufacture, to pharmaceutical compositions containing them and to methods of using such guanidine derivatives and compositions. The guanidine derivatives are of the general formula I: STR1 in which X is S or NH, Y is O, S, or SO, m is 1 to 4 and n is suitably 1 to 4, R 1 is hydrogen, halogen or alkyl, R 2 is hydrogen, alkyl, alkanoyl or aroyl, A is a 3,4-dioxocyclobuten-1,2-diyl radical or C=Z in which Z is O, S, NCN, NNO 2, CHNO 2, NCONH 2, C(CN) 2, NCOR 3, NCO. sub.2 R 3, NSO 2 R 3 or NR 4 in which R 3 is alkyl or aryl and R 4 is hydrogen or alkyl, B is alkoxy or alkylthio or NR 5 R 6 in which R 5 and R 6 are independently hydrogen, alkyl, alkenyl, cycloalkyl, hydroxyalkyl, alkoxyalkyl, alkylaminoalkyl or dialkylaminoalkyl; and the salts thereof.
