81153-45-9

Upstream product

• 81153-42-6 4-Chloro-3-methyl-1-phenylpyrazolo<3,4-b>pyridine-5-carboxylic acid 
• 1131-18-6 1-Phenyl-3-methyl-5-aminopyrazole 
• 81153-44-8 4-chloro-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester 
• 110299-41-7 2-[(5-methyl-2-phenyl-2H-pyrazol-3-ylamino)methylene]malonic acid diethyl ester 

Downstream Products

• 851520-98-4 4-chloro-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid amide 
• 81153-41-5 1,6-Diphenyl-8-methyl-1H,6H-dipyrazolo<3,4-b:3',4'-d>pyridin-3-one 

Relevant academic research and scientific papers

Discovery of new orally active phosphodiesterase (PDE4) inhibitors

A series of 4-anilinopyrazolopyridine derivatives were synthesized and biologically evaluated as inhibitors of phosphodiesterase (PDE4). Chemical modification of 3, a structurally new chemical lead that was found in our in-house library, was focused on 1- and 3-substituents. Full details of the discovery of a new orally active chemical lead 5 are presented. Structure-activity relationship data, pharmacological evaluation, and the subtype selectivity study are also presented.

Tricyclic Heteroaromatic Ring Systems III. Synthesis of 1H,6H-Dipyrazolopyridin-3-ones

The reaction of hydrazines with substituted ethyl 4-chloro-1H-pyrazolopyridine-3-carboxylates leads to the formation of 1H,6H-dipyrazolopyridin-3-ones. - Keywords: Pyrazolopyridines; Ring closures