81165-29-9

Upstream product

• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 81165-22-2 2-(3,4-Dichloro-phenyl)-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-acetamide 
• 5807-30-7 3,4-dichlorophenyl acetic acid 
• 258520-82-0 1-(3,4-Dichloro-benzyl)-6,7-dimethoxy-3,4-dihydro-isoquinoline 

Downstream Products

• 64229-14-7 C₄₆H₅₄Cl₄N₂O₈⁽²⁺⁾*2CH₃O₃S^(1-) 
• 81165-41-5 3-[1-(3,4-Dichloro-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-propionic acid 2-{3-[1-(3,4-dichloro-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-propionyloxy}-ethyl ester; compound with oxalic acid 

Relevant academic research and scientific papers

1,2,3,4-tetrahydroisoquinoline derivatives

The invention relates to novel 1,2,3,4-tetrahydroisochinoline derivatives of formula (I) and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.

Synthesis of 6,7-dimethoxy-1-halobenzyl-1,2,3,4-tetrahydroisoquinolines

Some 6,7-dimethoxy-1-halobenzyl-1,2,3,4-tetrahydroisoquinolines were synthesized from 2-(3,4-dimethoxyphenyl)ethylamine and halophenylacetic acids in three steps in good yield.