81187-70-4Relevant academic research and scientific papers
A simple synthesis of Δ2-oxazolines, Δ2-oxazines, Δ2-thiazolines and 2-substituted benzoxazoles
Vorbruggen,Krolikiewicz
, p. 9353 - 9372 (1993)
Carboxylic acids react readily at 0° ← + 24°C with amino alcohols, amino mercaptans and o-aminophenols in the presence of triphenylphosphine- or tributylphosphine dichloride (generated in situ from the reaction of the phosphines with hexacholoroethane or CCl4) and triethylamine in acetonitrile to form the corresponding Δ2-oxazolines, Δ2-oxazines, Δ2-thiazolines and 2-substituted benzoxazoles in one reaction step in yields of up to 80%.
Chiral 3-(4,5-dihydrooxazol-2-yl)phenyl alkylcarbamates as novel FAAH inhibitors: Insight into FAAH enantioselectivity by molecular docking and interaction fields
Myllymaeki, Mikko J.,Kaesnaenen, Heikki,Kataja, Antti O.,Lahtela-Kakkonen, Maija,Saario, Susanna M.,Poso, Antti,Koskinen, Ari M.P.
experimental part, p. 4179 - 4191 (2009/12/04)
Fatty acid amide hydrolase (FAAH) and monoglyceride lipase (MGL) are the main enzymes responsible for the hydrolysis of endogenous cannabinoids N-arachidonoylethanolamide (AEA) and 2-arachidonoylglycerol (2-AG), respectively. Phenyl alkylcarbamates are FA
HETEROCYCLIC PHENYL CARBAMATES AS NOVEL FAAH-INHIBITORS
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Page/Page column 49, (2008/12/08)
Fatty acid amide hydrolase inhibitors of the Formula (I) are provided, wherein R is a heterocyclic or heterocyclic carbonyl moiety and R' is a group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted
A SIMPLE SYNTHESIS OF Δ2-OXAZOLINES, Δ2-OXAZINES, Δ2-THIAZOLINES AND Δ2-IMIDAZOLINES
Vorbrueggen, Helmut,Krolikiewicz, Konrad
, p. 4471 - 4474 (2007/10/02)
Carboxylic acids react with amino alcohols, amino mercaptans or diamines in the presence of triphenylphosphine, CCl4 and tert. bases to afford in 50-75percent yield the corresponding Δ2-oxazolines, Δ2-oxazines, Δ2-thiazolines and Δ2-imidazolines.
