81187-71-5Relevant academic research and scientific papers
A 2 - substituted oxazoline or 2 - substituted piperazine synthetic method (by machine translation)
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Paragraph 0021; 0032, (2017/08/25)
The invention discloses a method for synthesizing 2 - substituted oxazoline or 2 - substituted oxazine new method, by nitrile and amino ethanol or 3 - amino - 1 - propanol as raw material, in the absence of solvent, can be used for the recycling of the sulfur to induce synthesis of 2 - substituted oxazoline and 2 - substituted piperazine. The method of the invention has low cost, simple reaction process, mild reaction conditions, the reaction time is short, the yield and the like, is suitable for the industrial generation. (by machine translation)
S-Co(II) cascade catalysis: Cyclocondensation of aromatic nitriles with alkamine
Ge, Haixia,Liu, Ping,Li, Xiangnan,Sun, Wei,Li, Jianli,Yang, Bingqin,Shi, Zhen
, p. 6591 - 6597 (2013/07/26)
A solvent-free S/Co(NO3)2 cascade catalyzed cyclocondensation reaction of aromatic nitriles with 3-amino-1-propanol or 2-aminoethanol has been successfully developed under thermal and microwave conditions. By this two-component protocol, mono- and bis-oxazines and oxazolines were selectively synthesized both in good to excellent yields and short reaction times. This catalytic system exhibits excellent chemoselectivity, and can be reused at least seven times without significant loss of activity in subsequent reactions.
Synthesis and biological activities of 4-N-(anilinyl-n-[oxazolyl])-7- chloroquinolines (n = 3′ or 4′) against Plasmodium falciparum in in vitro models
Gordey, Erin E.,Yadav, Paras N.,Merrin, Marcus P.,Davies, Jill,Ward, Steven A.,Woodman, Grant M.J.,Sadowy, Amber L.,Smith, Todd G.,Gossage, Robert A.
scheme or table, p. 4512 - 4515 (2011/09/15)
The synthesis (Pd-mediated coupling strategy) and characterization (NMR, IR, elemental analysis, etc.) of a short series of quinoline-oxazole hybrid compounds has been carried out. These materials are found to be moderately active against Plasmodium falci
Oxazoline or oxazine acetoacetate aqueous coating compositions
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, (2008/06/13)
A novel compound having the formula: wherein R is an alkyl group containing 1-5 carbon atoms or an aryl, substituted aryl, substituted or unsubstituted heteroaryl, alkyl-aryl, alkylether-aryl or O; R1and R2are hydrogen or a methyl gr
A simple synthesis of Δ2-oxazolines, Δ2-oxazines, Δ2-thiazolines and 2-substituted benzoxazoles
Vorbruggen,Krolikiewicz
, p. 9353 - 9372 (2007/10/02)
Carboxylic acids react readily at 0° ← + 24°C with amino alcohols, amino mercaptans and o-aminophenols in the presence of triphenylphosphine- or tributylphosphine dichloride (generated in situ from the reaction of the phosphines with hexacholoroethane or CCl4) and triethylamine in acetonitrile to form the corresponding Δ2-oxazolines, Δ2-oxazines, Δ2-thiazolines and 2-substituted benzoxazoles in one reaction step in yields of up to 80%.
A SIMPLE SYNTHESIS OF Δ2-OXAZOLINES, Δ2-OXAZINES, Δ2-THIAZOLINES AND Δ2-IMIDAZOLINES
Vorbrueggen, Helmut,Krolikiewicz, Konrad
, p. 4471 - 4474 (2007/10/02)
Carboxylic acids react with amino alcohols, amino mercaptans or diamines in the presence of triphenylphosphine, CCl4 and tert. bases to afford in 50-75percent yield the corresponding Δ2-oxazolines, Δ2-oxazines, Δ2-thiazolines and Δ2-imidazolines.
