81189-31-3Relevant academic research and scientific papers
Evaluation of the amino acid binding site of Mycobacterium tuberculosis glutamine synthetase for drug discovery
Nordqvist, Anneli,Nilsson, Mikael T.,Roettger, Svenja,Odell, Luke R.,Krajewski, Wojciech W.,Evalena Andersson,Larhed, Mats,Mowbray, Sherry L.,Karlen, Anders
, p. 5501 - 5513 (2008/12/20)
A combination of a literature survey, structure-based virtual screening and synthesis of a small library was performed to identify hits to the potential antimycobacterial drug target, glutamine synthetase. The best inhibitor identified from the literature
Ureido substituted benzoic acid compounds and their use for nonsense suppression and the treatment of disease
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Page/Page column 50, (2008/06/13)
The invention encompasses ureido substituted benzoic acid compounds, compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA by administering these compounds or compositions.
Copper-catalyzed aryl amination in aqueous media with 2- dimethylaminoethanol ligand
Lu, Zhikuan,Twieg, Robert J.
, p. 2997 - 3001 (2007/10/03)
Copper-catalyzed amination of aryl bromides and iodides under mild conditions has been developed with 2-dimethylaminoethanol as ligand and water as solvent. A variety of hydrophilic and hydrophobic aryl halide substrates have been aminated in good yield with a variety of amino acids, amino alcohols and peptides. This method has successfully N-arylated some hydrophilic amino compounds not available by other methods.
Novel analogues of sydnone: Synthesis, characterization and antibacterial evaluation
Moustafaa, Mohamed A.,Gineinah, Magdy M.,Nasr, Magda N.,Bayoumi, Waleed A. H.
, p. 427 - 433 (2007/10/03)
New sydnone derivatives bearing a substituted phenyl ring at the 3-position nave been synthesized. Two separate series of 3-(carboxyphenyl)sydnone derivatives have been prepared by cyclization of the corresponding N-nitroso-N-(carboxyphenyl)-glycine 3. The obtained 3-(carboxyphenyl)sydnones 4 were subjected to a series of different chemical reactions on the carboxylic acid group. Compound 5, the potassium salt of 4a, was reacted with α-chloroacetanilide derivatives 6 to give the corresponding esters 7. On the other hand, the acid hydrazide 9 was condensed with different aromatic aldehydes to give the corresponding arylidene derivatives 10. The synthesized compounds were tested for their antibacterial activities against both gram-positive and gram-negative organisms. Some of the test compounds exhibited high activity; among them, 10d is considered to be a lead compound possessing high broad-spectrum antibacterial activity.
