81222-47-1

Upstream product

• 100-52-7 benzaldehyde 
• 24512-96-7 ethyl (Z)-2-azido-3-phenylacrylate 
• 603-35-0 triphenylphosphine 

Downstream Products

• 129990-88-1 C₃₁H₂₉NO₃P⁽¹⁺⁾*Cl^(1-) 
• 496965-46-9 3-(3-Chloro-phenyl)-2-dihexylamino-5-[1-phenyl-meth-(Z)-ylidene]-3,5-dihydro-imidazol-4-one 
• 496965-40-3 3-(3-Chloro-phenyl)-2-dipentylamino-5-[1-phenyl-meth-(Z)-ylidene]-3,5-dihydro-imidazol-4-one 
• 499132-90-0 3-(3-Chloro-phenyl)-2-dibutylamino-5-[1-phenyl-meth-(Z)-ylidene]-3,5-dihydro-imidazol-4-one 
• 496965-63-0 3-(3-Chloro-phenyl)-2-diisobutylamino-5-[1-phenyl-meth-(Z)-ylidene]-3,5-dihydro-imidazol-4-one 

Relevant academic research and scientific papers

Formal [4+2]-annulation of vinyl azides with N-unsaturated aldimines

Highly functionalized quinolines and pyridines could be synthesized by BF3?OEt2-mediated reactions of vinyl azides with N-aryl and N-alkenyl aldimines, respectively. The reaction mechanism could be characterized as formal [4+2]-annulation, including unprecedented enamine-type nucleophilic attack of vinyl azides to aldimines and subsequent nucleophilic cyclization onto the resulting iminodiazonium ion moieties.

Synthesis, proton and 13C NMR and reaction mechanism studies of novel isoindolones derivatives, obtained through TAWERS procedure

A series of novel isoindolone derivatives (13-18) were prepared in goods yields by applying the TAWERS methodology. A general approach for formation of isoindolones from the aza-Wittig reaction of iminophosphoranes with dialdehydes under neutral and mild conditions was realized. Using 1D NMR a [1,3]-hydride migration was detected. The assignment of the structures and conformation behavior of the derivatives was achieved using 1D and 2D NMR (NOESY, DEPT, HMQC, and HMBC).

An efficient synthesis of double 2-alkylthio-5-phenylmethylidene-4H- imidazol-4-ones

Double 2-alkylthio-5-phenylmethylidene-4H-imidazol-4-ones 6 were synthesized by S-alkylation of double 2-thioxo-5-phenylmethylidene-4- imidazolidinone 5, which was obtained via cyclization of vinyl isothiocyanate 4 with ethylenediamine.

A rapid parallel synthesis of 2-dialkylamino-4H-imidazolin-4-ones

2-Dialkylamino-4H-imidazolin-4-ones 6 were rapidly synthesized by a solution-phase parallel synthetic method, which includes Aza-Wittig reaction of iminophosphorane 3 with aromatic isocynate to give carbodiimide 4 and subsequent reaction of 4 with various

α,β-Unsaturated Carboxylic Acid Derivatives. XXI. A Novel Synthesis of α-Dehydroamino Acid Derivatives by the Arbusov Reaction of α-Phosphoranylideneamino-2-alkenoates

The reaction of ethyl 2-azido-2-alkenoate with organic tervalent phosphorus reagent gave the corresponding 2-phosphoranylideneamino derivative as an stable intermediate.This transformed gradually at room temperature, or immediately on a silica-gel column