81226-60-0 Usage
Uses
Different sources of media describe the Uses of 81226-60-0 differently. You can refer to the following data:
1. L-741,626 is a selective D2DR inhibitor. Also, it is a G protein-coupled receptors antagonists and inverse agonists.
2. L-741,626 has been used as selective dopamine (D2) receptor antagonist to study its effects on the uptake of dopamine in human embryonic kidney 293 (HEK293) cells. It has also been used as a D2 receptor antagonist to study its effects on thyrotropin-releasing hormone (TRH) induced prolactin release.
Hazard
A poison.
Biochem/physiol Actions
L-741,626 is a selective dopamine (D2) receptor antagonist.
Check Digit Verification of cas no
The CAS Registry Mumber 81226-60-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,2,2 and 6 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 81226-60:
(7*8)+(6*1)+(5*2)+(4*2)+(3*6)+(2*6)+(1*0)=110
110 % 10 = 0
So 81226-60-0 is a valid CAS Registry Number.
InChI:InChI=1/C20H21ClN2O/c21-17-7-5-16(6-8-17)20(24)9-11-23(12-10-20)14-15-13-22-19-4-2-1-3-18(15)19/h1-8,13,22,24H,9-12,14H2
81226-60-0Relevant articles and documents
Synthesis and characterization of selective dopamine D2 receptor antagonists
Vangveravong, Suwanna,McElveen, Elizabeth,Taylor, Michelle,Xu, Jinbin,Tu, Zhude,Luedtke, Robert R.,Mach, Robert H.
, p. 815 - 825 (2006)
A series of indole compounds have been prepared and evaluated for affinity at D2-like dopamine receptors using stably transfected HEK cells expressing human D2, D3, or D4 dopamine receptors. These compounds shar
Antipsychotic piperidinomethyl-indole derivatives
-
, (2008/06/13)
The invention relates to compounds of formula II STR1 and their pharmaceutically acceptable salts wherein R5 represents hydrogen, acyl, lower alkyl or cycloalkyl; R6 represents hydrogen, halogen, trifluormethyl, or lower alkyl; Rsup
