81226-68-8

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
5-bromo-2-chlorobenzene-1-sulfonyl chloride is used as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its reactivity and sulfonylating properties enable the creation of a wide range of bioactive compounds with potential therapeutic and pesticidal properties.
Used in Dye and Pigment Production:
This chemical compound is also an important intermediate in the production of dyes and pigments. Its unique structure allows for the development of novel colorants with specific properties, such as improved stability and color intensity.
Used in Research and Development:
5-bromo-2-chlorobenzene-1-sulfonyl chloride is highly sought after in the research and development of new materials and products across various industries. Its versatility and reactivity make it a valuable tool for exploring innovative applications and advancing scientific knowledge.

InChI:InChI=1/C6H3BrCl2O2S/c7-4-1-2-5(8)6(3-4)12(9,10)11/h1-3H

Upstream product

• 60811-17-8 5-bromo-2-chloroaniline 
• 15327-48-7 5-bromo-2-chloroaniline hydrochloride 

Downstream Products

• 1106313-68-1 5-bromo-2-chloro-benzenesulfonic acid anilide 
• 1188410-18-5 4-(5-bromo-2-chloro-benzenesulfonyl)-morpholine 
• 1377551-26-2 5-(2-amino-4-(2,2,2-trifluoroethoxy)pyrimidin-5-yl)-2-chloro-N-(2,3-difluorophenyl)benzenesulfonamide 
• 1377551-23-9 5-(2-amino-4-methoxypyrimidin-5-yl)-2-chloro-N-(2,3-difluorophenyl)benzenesulfonamide 
• 1377551-20-6 5-(2-aminopyrimidin-5-yl)-2-chloro-N-(2,3-difluorophenyl)benzenesulfonamide 

Relevant academic research and scientific papers

Discovery of a novel series of potent and orally bioavailable phosphoinositide 3-kinase γ inhibitors

The phosphoinositide 3-kinases (PI3Ks) have been linked to an extraordinarily diversified group of cellular functions making these enzymes compelling targets for the treatment of disease. A large body of evidence has linked PI3Kγ to the modulation of autoimmune and inflammatory processes making it an intriguing target for drug discovery. Our high-throughput screening (HTS) campaign revealed two hits that were nominated for further optimization studies. The in vitro activity of the first HTS hit, designated as the sulfonylpiperazine scaffold, was optimized utilizing structure-based design. However, nonoptimal pharmacokinetic properties precluded this series from further studies. An overlay of the X-ray structures of the sulfonylpiperazine scaffold and the second HTS hit within their complexes with PI3Kγ revealed a high degree of overlap. This feature was utilized to design a series of hybrid analogues including advanced leads such as 31 with desirable potency, selectivity, and oral bioavailability.

COMPOUNDS FOR THE TREATMENT AND PREVENTION OF INFLUENZA

A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R4 and Ar are as defined in description and in claims, can be used as a medicament.

COMPOUNDS FOR THE TREATMENT AND PREVENTION OF INFLUENZA

A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R4 and Ar are as defined in description and in claims, can be used as a medicament.

COMPOUNDS FOR THE TREATMENT AND PREVENTION OF INFLUENZA

A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R4 and Ar are as defined in description and in claims, can be used as a medicament.

ORGANIC COMPOUNDS

The present invention concerns a compound of formula (I) or a salt, suitably a pharmaceutically acceptable salt, or solvate thereof, wherein the groups R1, R2, Ar', A and B are defined in the description, to compositions a

Organic compounds

The present invention concerns a compound of formula (I) or a salt, suitably a pharmaceutically acceptable salt, or solvate thereof, wherein the groups R1, R2, Ar′, A and Y are defined in the description, to compositions and use of the compounds in the treatment of inflammatory and allergic conditions.

2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS

The present invention is directed to 2-phenyl-indole compounds (A), their preparation, pharmaceutical compositions containing these compounds, and their pharmaceutical use in treating a patient suffering from a PGD2-mediated disorder including, but not li

2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS

The present invention is directed to a compound of Formula (XVI) wherein R, R2, R3, R4, R5, R6, R7 and n are as defined herein, or a pharmaceutically acceptable salt, hydrate, or solvate thereof, a pharmaceutically acceptable prodrug thereof, or a pharmac