81245-39-8

Upstream product

• 150-19-6 O-methylresorcine 
• 57234-28-3 1-methoxy-3-(methoxymethoxy)benzene 

Downstream Products

• 121980-50-5 2-iodo-3-(methyloxy)phenol 
• 1042073-40-4 5-(2,6-dimethoxyphenyl)pent-4-yn-1-ol 
• 16932-44-8 2-iodo-1,3-dimethoxybenzene 
• 1380696-16-1 (5R)-3-{4-[(3,3-dimethyl-2,3-dihydro-1-benzofuran-4-yl)oxy]phenyl}-5-methyl-2,4-imidazolidinedione 
• 1380697-48-2 2-iodo-1-(methyloxy)-3-[(2-methyl-2-propen-1-yl)oxy]benzene 
• 1380697-56-2 N₁-{4-[(3,3-dimethyl-2,3-dihydro-1-benzofuran-4-yl)oxy]phenyl}-D-alaninamide 
• 1380697-55-1 1,1-dimethylethyl [(1R)-2-({4-[(3,3-dimethyl-2,3-dihydro-1-benzofuran-4-yl)oxy]phenyl}amino)-1-methyl-2-oxoethyl]carbamate 
• 1380697-54-0 4-[(3,3-dimethyl-2,3-dihydro-1-benzofuran-4-yl)oxy]aniline 
• 1380697-53-9 3,3-dimethyl-4-[(4-nitrophenyl)oxy]-2,3-dihydro-1-benzofuran 
• 1232362-02-5 3,3-dimethyl-2,3-dihydro-1-benzofuran-4-ol 
• 104886-34-2 2-Iodo-1-methoxy-3-prop-2-ynyloxy-benzene 
• 104886-33-1 (E)-4-(2-Iodo-3-methoxy-phenoxy)-but-2-enoic acid ethyl ester 
• 104886-35-3 (E)-3-Phenyl-acrylic acid 2-iodo-3-methoxy-phenyl ester 
• 104886-31-9 2-Iodo-1-methoxy-3-((E)-3-phenyl-allyloxy)-benzene 

Relevant academic research and scientific papers

Regioselectivity Influences in Platinum-Catalyzed Intramolecular Alkyne O-H and N-H Additions

The steric and electronic drivers of regioselectivity in platinum-catalyzed intramolecular hydroalkoxylation are elucidated. A branch point is found that divides the process between 5-exo and 6-endo selective processes, and enol ethers can be accessed in good yields for both oxygen heterocycles. The main influence arises from an electronic effect, where the alkyne substituent induces a polarization of the alkyne that leads to preferential heteroatom attack at the more electron-deficient carbon. The electronic effects are studied in other contexts, including hydroacyloxylation and hydroamination, and similar trends in directionality are predominant although not uniformly observed.

NOVEL COMPOUNDS

The invention provides compounds of formula (I): Said compounds being modulators of Kv3 channels and of use in the prophylaxis or treatment of related disorders.

HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS

The invention provides compounds of formula (I): Said compounds being modulators of Kv3 channels and of use in the prophylaxis or treatment of related disorders.

HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS

The invention provides compounds of formula (I): Said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.

HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS

The invention provides compounds of formula (I): Said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.

3-PHENOXY-4-PYRIDAZINOL DERIVATIVE AND HERBICIDE COMPOSITION CONTAINING THE SAME

A compound represented by the formula: wherein R1 represents a hydrogen atom, a halogen atom, alkyl group, etc., ???R2 represents a hydrogen atom, a halogen atom, alkyl group, etc., ???R3, R4, R5, R6 and R7 each independently represent a hydrogen atom, a halogen atom, a substitutable alkyl group, a substitutable alkenyl group, alkynyl group, a substitute-able cycloalkyl group, etc., or adjacent two of R3, R4, R5, R6 and R7 may together with the carbon atoms to which the respective substituents are bonded form a ring which may be substituted, ???m and n each independently represent 0 or 1, a salt thereof or an ester derivative thereof; an agricultural chemical containing the same as an active ingredient; and a herbicidal composition containing the compound and a second herbicidally active compound as active ingredients.

SYNTHETIC CONNECTIONS TO THE AROMATIC DIRECTED METALATION REACTION. RADICAL-INDUCED CYCLIZATION TO SUBSTITUTED BENZOFURANS, BENZOPYRANS, AND FUROPYRIDINES

The ortho-iodoaryl allyl ethers 2, derived from 1 via the aromatic directed metalation protocol, undergo tributyl tin hydride-induced heteroring annelation to lead to unusually substituted benzofuran (3) and benzopyran, and furopyridine derivatives (Table).

REGIOSELECTIVE METALLATIONS OF (METHOXYMETHOXY)ARENES

The methoxymethoxy substituent when attached to an aromatic ring functions as a moderately strong ortho-directing group in hydrogen-metal exchenge reactions.In many cases the propensity of the methoxymethoxylated arene toward ring metallations is greatly enhanced with concomitant suppression of undesirable side reactions such as nucleophilic attack and addition of metallating species.Unlike many other ortho-directing groups, the regio-direction of the methoxymethoxy substituent when in conjunction with other weaker directing groups is dependent upon the metallating medium.Thus, by changing the electron donating capacity of the metallating medium it is possible to selectively direct metallation to either of the positions ortho to the methoxymethoxy substituent.

Regioselective Metalation Reactions of Some Substituted (Methoxymethoxy)arenes

The methoxymethoxy substituent acts as a relatively strong ortho-directing group in hydrogen-metal exchange reactions.However, the directing effects are influenced by the metalation medium, thus permitting an unusual degree of control of the site of metalation.In conjunction with weak ortho-directing groups, the metalation ortho to the methoxymethoxy group can be directed to either of the ortho positions by controlling the electron-donating capacity of the metalating solvent.In strongly donating solvents the 1,2,4-substitution pattern will arise from a meta-substituted methoxymethoxy arene, while in nondonating solvents the 1,2,3-substitution is favored.In addition, the methoxymethoxy group serves also to enhance the rate of metalation and to stabilize the aryl-metalated products so that some competing addition reactions are supressed.