81255-66-5Relevant academic research and scientific papers
A practical copper-catalyzed approach to β-lactams: via radical carboamination of alkenyl carbonyl compounds
Shi, Peng,Wang, Jie,Gan, Zixu,Zhang, Jingyu,Zeng, Runsheng,Zhao, Yingsheng
, p. 10523 - 10526 (2019)
Functionalized β-lactams are highly important motifs in synthetic chemistry. We report an efficient and novel approach to the synthesis of β-lactams via a copper(i)-catalyzed cascade process involving C(benzyl)-H radical abstraction, intermolecular alkene addition, and intramolecular amination reaction. Variously substituted alkenes were synthesized from vinylacetic acid, leading to the corresponding β-lactams in moderate to good yields. Preliminary studies indicate that the reaction undergoes a free radical mechanism via a Cu(i)/Cu(ii)/Cu(iii) catalytic cycle.
The tandem Heck-allylic substitution reaction: a novel route to lactams.
Pinho, Pedro,Minnaard, Adriaan J,Feringa, Ben L
, p. 259 - 261 (2007/10/03)
[reaction: see text] A novel route to substituted lactams has been developed using a tandem Heck-allylic substitution reaction. The palladium-catalyzed reaction between omega-olefinic N-tosyl amides and vinylic bromides affords in one step the substituted
