81255-79-0

Upstream product

• 81255-73-4 4-Iodomethyl-1-(toluene-4-sulfonyl)-azetidin-2-one 
• 201230-82-2 carbon monoxide 
• 25856-77-3 1-tosyl-2-methylaziridine 
• 81255-66-5 N-tosylbut-3-enamide 
• 116241-32-8 4-Methyl-1-(toluene-4-sulfonyl)-azetidine-2,2-dicarboxylic acid dimethyl ester 
• 116241-37-3 4-Methyl-1-(toluene-4-sulfonyl)-azetidine-2,2-dicarboxylic acid 
• 81255-72-3 4-Bromomethyl-1-(toluene-4-sulfonyl)-azetidin-2-one 
• 116331-26-1 2-[2-(Toluene-4-sulfonylamino)-propyl]-malonic acid dimethyl ester 

Relevant academic research and scientific papers

General and highly efficient synthesis of 2-alkylideneazetidines and β-lactams via copper-catalyzed intramolecular N-vinylation

N-Tosyl-3-halo-3-butenylamines underwent efficient Ullmann-type coupling with the catalysis of Cul/N,N-dimethylethylenediamine to afford 2-alkylideneazetidines, which could be readily converted to the corresponding β-lactams by oxidation with O3/sub

[Lewis acid]+[Co(CO)4]- complexes: A versatile class of catalysts for carbonylative ring expansion of epoxides and aziridines

Efficient carbonyl insertion into C-O and C-N bonds using [Lewis acid]+[Co(CO)4]- complexes 1 and 2 gives regio- and stereoselective carbonylation of a variety of epoxides and aziridines to yield β-lactones and β-lactams, respectively. Both transformations are proposed to occur by the same mechanism, yielding products with inversion of configuration at the site of CO insertion.

A New Anodic C-N Bond Forming Reaction Useful to Formation of Aziridine, Azetidine, and Pyrrolidine Rings

Aziridine, azetidine, and pyrrolidine rings were formed in high yields by oxidation of the corresponding dimethyl α-(ω-tosylaminoalkyl)malonates in methanol containing KI as a mediator.