81258-24-4

Usage

General Description

3-(4-Bromo-2-methoxyphenoxy)propanoic acid is a chemical compound with the molecular formula C10H11BrO4. It is a derivative of propanoic acid and contains a bromine atom and a methoxy group attached to a phenyl ring. 3-(4-Bromo-2-methoxyphenoxy)propanoic acid is commonly used as a pharmaceutical intermediate in the synthesis of potential drugs. It may also have potential applications in the fields of agrochemicals and materials science. However, due to its specific chemical structure, it is important to handle 3-(4-Bromo-2-methoxyphenoxy)propanoic acid with caution and follow safety protocols when using it in laboratory or industrial settings.

Upstream product

• 57-57-8 β-Propiolactone 
• 7368-78-7 4-bromoguaiacol 
• 90-05-1 2-methoxy-phenol 
• 590-92-1 3-Bromopropionic acid 

Downstream Products

• 81258-07-3 5-methoxy-7,8-dihydropyrano<2,3-g>indol-9 
• 81258-05-1 acide methoxy-5 oxo-9 dihydro-7,8 pyranno<2,3-g>indolecarboxylique-2 

Relevant academic research and scientific papers

BCL-2 INHIBITOR

Disclosed herein is a compound of Formula (I) for inhibiting both Bcl-2 wild type and mutated Bcl-2, in particular, Bcl-2 G101V and D103Y, and a method of using the compound disclosed herein for treating dysregulated apoptotic diseases.

PYRIMIDINE DERIVATIVES AS PGE2 RECEPTOR MODULATORS

The present invention relates to pyrimidine derivatives of formula (I) wherein (R1)n, R3, R4a, R4b, R5a, R5b and Ar1 are as described in the description and their use in the treatment of cancer by modulating an immune response comprising a reactivation of the immune system in the tumor. The invention further relates to novel benzofurane and benzothiophene derivatives of formula (II) and their use as pharmaceuticals, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as modulators of the prostaglandin 2 receptors EP2 and/or EP4.

Synthese d'oxopyrannoindoles

Reaction of ethyl azidoacetate with 6-formyl-4 chromanones, followed by cyclization of the azides obtained leads to 7,8-dihydropyranoindol-9 (1H)-one.One aspect of the chemical reactivity of these new tricyclic systems is described.The structure of the compounds isolated from various syntheses is established by proton nmr data.