81258-25-5Relevant academic research and scientific papers
Dynamic Kinetic Resolution of Alcohols by Enantioselective Silylation Enabled by Two Orthogonal Transition-Metal Catalysts
Oestreich, Martin,Seliger, Jan
, p. 247 - 251 (2021)
A nonenzymatic dynamic kinetic resolution of acyclic and cyclic benzylic alcohols is reported. The approach merges rapid transition-metal-catalyzed alcohol racemization and enantioselective Cu-H-catalyzed dehydrogenative Si-O coupling of alcohols and hydrosilanes. The catalytic processes are orthogonal, and the racemization catalyst does not promote any background reactions such as the racemization of the silyl ether and its unselective formation. Often-used ruthenium half-sandwich complexes are not suitable but a bifunctional ruthenium pincer complex perfectly fulfills this purpose. By this, enantioselective silylation of racemic alcohol mixtures is achieved in high yields and with good levels of enantioselection.
Synthese d'oxopyrannoindoles
Kim, Phieo Ta,Cocolios, Panayotis,Guilard, Roger
, p. 2099 - 2103 (2007/10/02)
Reaction of ethyl azidoacetate with 6-formyl-4 chromanones, followed by cyclization of the azides obtained leads to 7,8-dihydropyranoindol-9 (1H)-one.One aspect of the chemical reactivity of these new tricyclic systems is described.The structure of the compounds isolated from various syntheses is established by proton nmr data.
