81278-52-6

Basic information

• Product Name: (E,Z)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-phenyl-2-(3,4,5-tribromophenyl)-1-butene
• CAS NO: 81278-52-6
• Molecular Weight: 608.211
• Mol File: 81278-52-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E,Z)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-phenyl-2-(3,4,5-tribromophenyl)-1-butene(CAS DataBase Reference)
• NIST Chemistry Reference: (E,Z)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-phenyl-2-(3,4,5-tribromophenyl)-1-butene(81278-52-6)
• EPA Substance Registry System: (E,Z)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-phenyl-2-(3,4,5-tribromophenyl)-1-butene(81278-52-6)

Safety Data

• Hazardous Substances Data: 81278-52-6(Hazardous Substances Data)

Upstream product

• 106-41-2 4-bromo-phenol 
• 2474-07-9 [2-(4-bromophenoxy)ethyl]dimethylamine 
• 81278-49-1 2-phenyl-2-(3,4,5-tribromobenzyl)-1,3-dithiane 
• 81278-51-5 1-phenyl-2-(3,4,5-tribromophenyl)-1-butanone 
• 81278-50-4 1-phenyl-2-(3,4,5-tribromophenyl)-1-ethanone 
• 81278-48-0 1-(bromomethyl)-3,4,5-tribromobenzene 
• 73557-59-2 1-methyl-3,4,5-tribromobenzene 
• 5425-44-5 2-Phenyl-[1,3]dithiane 
• 81278-55-9 1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-hydroxy-1-phenyl-2-(3,4,5-tribromophenyl)butane 

Relevant articles and documents

Synthesis of the E and Z Isomers of the Antiestrogen Tamoxifen and Its Metabolite, Hydroxytamoxifen, in Tritium-Labeled Form

Both isomers of the potent antiestrogen tamoxifen (1,2-diphenyl-1-phenyl>-1-butene: E isomer = ICI-47699; Z isomer = ICI-46474, Nolvadex) and its metabolite, hydroxytamoxifen (1-phenyl>-1-(4-hydroxyphenyl)-2-phenyl-1-butene), have been synthesized in a high specific activity, tritium-labeled form by catalytic tritium-halogen exchange performed on brominated precursors.The synthesis of another precursor to labeled tamoxifen which would enable the incorporation of three tritium atoms into the molecule by tritium-halogen exchange is reported.