81328-71-4

Upstream product

• 81328-70-3 4-(2-methoxy-4-methylphenyl)-4-methylspiro<2.4>heptane 
• 943155-19-9 3-(2-methoxy-4-methylphenyl)-2,2,3-trimethylcyclopentanone 

Relevant academic research and scientific papers

Convenient formal synthesis of (±)-cuparene, (±)-enokipodins A and B, and (±)-cuparene-1,4-quinone

A Bronsted or Lewis acid mediated semi-pinacolic rear-rangement effected on the diastereomers of cyclobutanol derivatives leads efficiently to useful intermediates in the synthesis of cuparene-type sesquiterpenes. The cyclobutanols are themselves easily o

Synthesis of dl-3-Hydroxycuparene by a Claisen Rearrangement of Allyl Aryl Ether

The Claisen rearrangement of 1-methyl-2-cyclopentene in N,N-dimethylformamide gave 5-methyl-2-(1-methyl-2-methylenecyclopentyl)phenol (5) via its trimethylsilyl ether. The methylation of 5, followed by a Simmons-Smith reaction and by the catalytic hydrogenolysis, afforded 3-hydroxycuparene.