81338-23-0

Usage

Uses

D-AP7 is 8-Bromo-cGMP.

Biological Activity

More active form of AP7.

InChI:InChI=1/C7H16NO5P/c8-6(7(9)10)4-2-1-3-5-14(11,12)13/h6H,1-5,8H2,(H,9,10)(H2,11,12,13)/t6-/m1/s1

Upstream product

• 137622-51-6 2-Acetylamino-2-[5-(dimethoxy-phosphoryl)-pentyl]-malonic acid diethyl ester 
• 111-24-0 1,5-dibromo-pentane 
• 258278-52-3 2-(N-phenylacetylamino)-7-phosphonoheptanoic acid 
• 85797-13-3 AP-7 
• 42757-42-6 diethyl 5-bromopentanephosphonate 
• 5183-26-6 diethyl acetamido(5-bromopentyl)malonate 
• 137622-48-1 2-Acetylamino-2-(5-phosphono-pentyl)-malonic acid diethyl ester 
• 85685-91-2 (N-acetylamino-6 bis-ethoxycarbonyl-6,6)-hexylphosphonate de diethyle 

Downstream Products

• 81338-23-0 D-2-amino-7-phosphonoheptanoate 
• 81338-23-0 2-amino-7-phosphono-heptanoic acid 

Relevant academic research and scientific papers

Involucrin gene expression promoter

PROBLEM TO BE SOLVED: To provide an involucrin gene expression promoter that has high effect of promoting involucrin gene expression, and is applied to the skin, to quickly increase involucrin concentrations, and markedly improving the barrier function. SOLUTION: An involucrin gene expression promoter contains at least one selected from a compound represented by the following formula (1) [where R1 and R2 are the same or different to represent a hydrogen atom, or a substituent. n is an integer of 1 or greater], a salt thereof, and their hydrates as an active ingredient. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPO&INPIT

Phosphorus-containing aminocarboxylic acids: XIII. Enzymatic synthesis of enantiomers of phosphonic aminocarboxylic acids

A method for preparing enantiomers of phosphonic aminocarboxylic acids is proposed.

Phosphorus-containing aminocarboxylic acids. VII. Asymmetric synthesis of ω-phosphono-α-aminocarboxylic acids

New asymmetric ω-phosphono-α-aminocarboxylic acids were synthesized by alkylation with ω-bromoalkylphosphonates of the glycine methylene group in the Ni(II) complex of the Schiff base derived from glycine and (S)- and (R)-2-N-(N-benzylprolyl)-o-aminobenzo

PHOSPHORUS-CONTAINING AMINOCARBOXYLIC ACIDS. COMMUNICATION IV. A CONVENIENT METHOD OF PHOSPHONIC ACIDS SYNTHESIS

The communication is concerned with the synthesis of phosphonic aminocarboxylic acids by phosphorylation of diethyl ω-halogen alkyl acetamidomalonates with tris(trimethylsilyl) phosphite, followed by alcoholysis and acid hydrolysis of the resulting intermediate esters.Key words: Phosphonic aminocarboxylic acids; tris(trimethylsilyl) phosphite; ω-halogenalkyl acetamidomalonates; phosphorylation; alcoholysis, hydrolysis

SYNTHESE D'ACIDES ω-AMINO-ω-CARBOXY-ALKYLPHOSPHONIQUES

ω-Amino ω-carboxyalkylphosphonic acids 1 synthesis is reviewed.For n = 4, 5, 6 a general, efficient and inexpensive synthesis is described; acetamido(ω-bromoalkyl)malonates 12 are prepared from commercial dibromoalkanes and acetamidomalonate using the phase transfer catalysis process, then condensed with triethylphosphite through an Arbuzov reaction.An acid hydrolysis followed by purification on Dowex gives aminophosphonic acids 1 (n = 4, 5, 6) with a 70percent overall yield.The lower acid 1 (n = 2) is obtained with an identical overall yield from acetamidomalonate and 2-haloethylphosphonate using also liquid-solid phase transfer catalysis.