813445-49-7Relevant academic research and scientific papers
Copper-catalyzed tandem reactions of 2-halobenzenamines with isothiocyanates under ligand- and base-free conditions
Guo, Yan-Jin,Tang, Ri-Yuan,Zhong, Ping,Li, Jin-Heng
, p. 649 - 652 (2010)
A ligand-free copper-catalyzed reaction of 2-halobenzenamines with isothiocyanates has been developed for the synthesis of 2-aminobenzothiazoles. In the presence of CuBr and TBAB (tetra-n-butyl ammonium bromide, additive), a variety of 2-halobenzenamines underwent the reaction with isothiocyanates at 40 °C, affording 2-aminobenzothiazoles in moderate to excellent yields. It is noteworthy that the reaction is conducted under mild, relatively low catalyst loading, and ligand- and base-free conditions.
Benzothiazolyl derivatives
-
Page 11, (2008/06/13)
The present invention relates to compounds of formula (I) wherein R1, R2, R3°R3a and R3b are as provided in the description, and pharmaceutically acceptable salts thereof, for use in the treatment and
