813459-61-9

Basic information

• Product Name: benzyl ((1S,2R)-2-hydroxy-1,2-diphenylethyl)carbamate
• Synonyms: benzyl ((1S,2R)-2-hydroxy-1,2-diphenylethyl)carbamate
• CAS NO: 813459-61-9
• Molecular Weight: 347.414
• Mol File: 813459-61-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: benzyl ((1S,2R)-2-hydroxy-1,2-diphenylethyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl ((1S,2R)-2-hydroxy-1,2-diphenylethyl)carbamate(813459-61-9)
• EPA Substance Registry System: benzyl ((1S,2R)-2-hydroxy-1,2-diphenylethyl)carbamate(813459-61-9)

Safety Data

• Hazardous Substances Data: 813459-61-9(Hazardous Substances Data)

Upstream product

• 23190-16-1 (1R,2S)-2-Amino-1,2-diphenylethanol 
• 501-53-1 benzyl chloroformate 
• 100-52-7 benzaldehyde 
• 383366-27-6 benzyl phenyl(phenylsulfonyl)methylcarbamate 

Downstream Products

• 813459-67-5 (2S,4S,5R)-2-Oxo-4,5-diphenyl-2λ⁴-[1,2,3]oxathiazolidine-3-carboxylic acid benzyl ester 
• 23204-70-8 (4S,5R)-4,5-diphenyl-1,3-oxazolidin-2-one 
• 813459-77-7 (4S,5R)-3-((S)-2-Methyl-propane-2-sulfinyl)-4,5-diphenyl-oxazolidin-2-one 

Relevant articles and documents

Asymmetric Transfer Hydrogenation: Dynamic Kinetic Resolution of α-Amino Ketones

A series of α-amino ketones were reduced using asymmetric transfer hydrogenation (ATH) through a dynamic kinetic resolution (DKR). The protecting group was matched to the reducing agent, and following optimization, a series of substrates were investigated, giving products in high diastereoselectivity, over 99% ee in several cases and full conversion. The methodology was applied to the enantioselective synthesis of an MDM2-p53 inhibitor precursor.

The Preparation of (1α,3β)-3-Hydroxycholestane-4,6-diene- 1,25-diol Diacetate from a 5,7-Diene Precursor: A New Method for the Synthesis of Heteroannular Dienes

Starting from the 7α-bromide 5a, a regioselective synthesis of (1α,3β)-3-hydroxycholestane-4,6-diene-1,25-diol diacetate (2) is described. The preparative removal of contaminating 5,7-diene 9 was accomplished by the formation of the corresponding Diels-Alder adduct 11. Acetylation of the diacetate 2 followed by acid-catalyzed elimination and rearrangement yielded styrene 13.