81356-72-1

Basic information

• Product Name: 1-ethoxymethyl-4,5-bis(methylthio)-2-phenylthioimidazole
• Synonyms: 1-ethoxymethyl-4,5-bis(methylthio)-2-phenylthioimidazole
• CAS NO: 81356-72-1
• Molecular Weight: 326.508
• Mol File: 81356-72-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-ethoxymethyl-4,5-bis(methylthio)-2-phenylthioimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ethoxymethyl-4,5-bis(methylthio)-2-phenylthioimidazole(81356-72-1)
• EPA Substance Registry System: 1-ethoxymethyl-4,5-bis(methylthio)-2-phenylthioimidazole(81356-72-1)

Safety Data

• Hazardous Substances Data: 81356-72-1(Hazardous Substances Data)

Upstream product

• 67319-06-6 1-ethoxymethyl-5-lithio-2-phenylthioimidazole 
• 81356-68-5 1-ethoxymethyl-5-methylthio-2-phenylthioimidazole 
• 624-92-0 Dimethyldisulphide 
• 81356-73-2 4-bromo-1-ethoxymethyl-5-methylthio-2-phenylthioimidazole 

Relevant articles and documents

Metallation and Metal-Halogen Exchange Reactions of Imidazoles

1-Ethoxymethyl-2-phenylthioimidazol-5-yl-lithium (4) has been prepared by metallation of 1-ethoxymethyl-2-phenylthioimidazole with n-butyl-lithium in ether or tetrahydrofuran and allowed to react with carbon dioxide, 4-methylbenzaldehyde, dimethyl disulphide, diphenyl disulphide, and the disulphide prepared from 2-mercaptoacetaldehyde diethyl acetal. 1-Ethoxymethyl-5-methylthio-2-phenylthioimidazol-4-yl-lithium (18) has been prepared via bromination of 1-ethoxymethyl-5-methylthio-2-phenylthioimidazole (9) and exchange of the bromine atom in the product (15) with n-butyl lithium.It has been treated with dimethyl disulphide, NN-dimethylformaldehyde, and carbon dioxide, to give the corresponding sulphide (14), aldehyde (16), and acid (17), respectively. 2,5(4)-Bis(phenylthio)imidazole (23) prepared by treatment of its 1-ethoxymethyl derivative (10) with acid, iodinated in the 4-position to yield 4(5)-iodo-2,5(4)-bis(phenylthio)imidazole (24).