81357-96-2

Usage

Molecular weight

279.31 g/mol This is the mass of one mole of 2(1H)-Isoquinolinecarboxylic acid, 1-(2-oxo-2-phenylethyl)-, ethyl ester, measured in grams.

Derivative of isoquinolinecarboxylic acid

The compound is derived from isoquinolinecarboxylic acid, which is a heterocyclic aromatic organic compound.

Ethyl ester group

The carboxylic acid functional group of the compound is esterified with an ethyl group (C2H5O-).

Potential medicinal properties

The compound is being studied for its possible effects on the central nervous system, including its potential as an anti-inflammatory and neuroprotective agent.

Potential uses

The compound is being investigated for its potential uses in treating conditions such as Alzheimer's disease and depression.

Further research needed

More research is needed to fully understand the pharmacological properties and potential applications of 2(1H)-Isoquinolinecarboxylic acid, 1-(2-oxo-2-phenylethyl)-, ethyl ester.

Upstream product

• 119-65-3 isoquinoline 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 541-41-3 chloroformic acid ethyl ester 
• 81357-90-6 2-Acetyl-isoquinolinium; chloride 
• 81357-89-3 2-(ethoxycarbonyl)isoquinolinium chloride 
• 98-86-2 acetophenone 
• 81357-91-7 (C₆H₅)C(OB(C₄H₉)2)CH₂ 

Relevant academic research and scientific papers

Facile addition of ketones to activated isoquinolines using N-methyl-2-pyrrolidinone

Ketones undergo a smooth addition to N-acylisoquinolinium ions in N-methyl-2-pyrrolidinone, under mild conditions, to produce 1-alkylated isoquinoline derivatives in excellent yields with high regioselectivity. The use of commercially available N-methyl-2

Synthesis of 1,2-dihydroisoquinolines by the reaction of isoquinoline with allyltributyltin or silyl enol ethers in the presence of N-acylating agents

Isoquinolines were allowed to react with allyltributyltin or silyl enol ethers in the presence of N-acylating agents to give 1-substituted 1,2-dihydroisoquinolines in good yields. When a chiral acid chloride was used for an activator, a high diastereosele

Addition of Trimethylsilyl Enol Ethers to Isoquinolinium Salts: A Facile Synthesis of 1-(2-Oxoalkyl)-2-(ethoxycarbonyl)(or acetyl)- 1,2-dihydroisoquinolines and Their Cyclization for the Synthesis of the Isoquinoline Alkaloid Skeleton

The addition of trimethylsilyl enol ethers to 2-acylisoquinolinium salts afforded 1-(2-oxoalkyl)-2-(ethoxycarbonyl)(or acetyl)-1,2-dihydroisoquinolines (3) in excellent yields.These compounds were cyclized with bases to give benzoquinolizine derivative

REACTION OF TRIMETHYLSILYL ENOL ETHERS WITH ISOQUINOLINIUM SALTS. A FACILE SYNTHESIS OF ETHYL 1-(2-OXOALKYL)-1,2-DIHYDROISOQUINOLINE-2-CARBOXYLATES AND THEIR CYCLIZATION

An efficient method is described for the synthesis of ethyl 1-(2-oxoalkyl)-1,2-dihydroisoquinoline-2-carboxylates by C-C bond formation between 2-ethoxycarbonylisoquinolinium chloride and trimethylsilyl enol ethers.The products were treated with a few bases to afford the corresponding pyridoisoquinoline derivatives.

ADDITION OF BORON ENOLATES TO ISOQUINOLINIUM SALTS : A FACILE SYNTHESIS OF 1-β-KETO SUBSTITUTED 2-ETHOXYCARBONYL-1,2-DIHYDROISOQUINOLINES AND THEIR CYCLIZATION

An efficient method to synthesize 1-β-keto substituted 2-ethoxycarbonyl (or 2-acetyl)-1,2-dihydroisoquinolines (3) is described, utilizing boron enolates and isoquinolinium salts.The products were treated with sodium ethoxide to afford the corresponding c