81371-06-4

Basic information

• Product Name: (S)-2-{(S)-2-[(S)-2-((2R,3S)-3-Amino-2-hydroxy-5-methyl-hexanoylamino)-4-methyl-pentanoylamino]-3-methyl-butyrylamino}-3-phenyl-propionic acid methyl ester; hydrochloride
• Synonyms: (S)-2-{(S)-2-[(S)-2-((2R,3S)-3-Amino-2-hydroxy-5-methyl-hexanoylamino)-4-methyl-pentanoylamino]-3-methyl-butyrylamino}-3-phenyl-propionic acid methyl ester; hydrochloride
• CAS NO: 81371-06-4
• Molecular Weight: 571.157
• Mol File: 81371-06-4.mol

Chemical Properties

• CAS DataBase Reference: (S)-2-{(S)-2-[(S)-2-((2R,3S)-3-Amino-2-hydroxy-5-methyl-hexanoylamino)-4-methyl-pentanoylamino]-3-methyl-butyrylamino}-3-phenyl-propionic acid methyl ester; hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-{(S)-2-[(S)-2-((2R,3S)-3-Amino-2-hydroxy-5-methyl-hexanoylamino)-4-methyl-pentanoylamino]-3-methyl-butyrylamino}-3-phenyl-propionic acid methyl ester; hydrochloride(81371-06-4)
• EPA Substance Registry System: (S)-2-{(S)-2-[(S)-2-((2R,3S)-3-Amino-2-hydroxy-5-methyl-hexanoylamino)-4-methyl-pentanoylamino]-3-methyl-butyrylamino}-3-phenyl-propionic acid methyl ester; hydrochloride(81371-06-4)

Safety Data

• Hazardous Substances Data: 81371-06-4(Hazardous Substances Data)

Upstream product

• 64490-39-7 N-phthalyl-L-leucinal 
• 2419-38-7 N-phthaloyl-(S)-leucine 
• 81322-83-0 (S)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-5-methyl-2-trimethylsilanyloxy-hexanenitrile 
• 77119-88-1 (3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-5-methyl hexanoic acid 
• 81322-85-2 (S)-2-{(S)-2-[(S)-2-((2R,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-5-methyl-hexanoylamino)-4-methyl-pentanoylamino]-3-methyl-butyrylamino}-3-phenyl-propionic acid methyl ester 
• 81322-90-9 phthalyl-L-leucinal cyanohydrin 
• 318464-20-9 (2R,3S)-3-amino-2-hydroxy-5-methylhexanoic acid 
• 3183-10-6 N-phthalimide-L-leucinyl chloride 

Relevant articles and documents

Renin Inhibitors. Substitution of the Leucyl Residues of Leu-Leu-Val-Phe-OCH3 with 3-Amino-2-hydroxy-5-methylhexanoic Acid

The 2S,3S and 2R,3S diastereoisomers of the hydroxy amino acid 3-amino-2-hydroxy-5-methylhexanoic acid (AHMHA) were synthesized and substituted for the leucyl residues of Leu-Leu-Val-Phe-OCH3 to yield the following analogues: AHMHA-Leu-Val-Phe-OCH3, AHMHA