81375-97-5

Usage

InChI:InChI=1/C11H11NO3S2/c1-16-11(17-2)7-10(13)8-3-5-9(6-4-8)12(14)15/h3-7H,1-2H3

Upstream product

• 75-15-0 carbon disulfide 
• 100-19-6 (4-nitrophenyl)ethanone 
• 74-88-4 methyl iodide 
• 41501-63-7 2,2-dichlorovinyl 4-nitrophenyl ketone 
• 5188-07-8 sodium thiomethoxide 

Downstream Products

• 13700-88-4 (Nitro-4 phenyl)-5 dithiole-1,2 thione-3 
• 124927-43-1 2-(4-nitrobenzoylmethylene)imidazolidine 
• 881889-88-9 3,3-bis(methylsulfanyl)-2-(4-nitrobenzoyl)acrylaldehyde 
• 881889-93-6 2-[3,3-bis(methylsulfanyl)-2-(4-nitrobenzoyl)-2-propenylidene]malononitrile 
• 134304-73-7 (E)-1-(4-nitrophenyl)-2-(oxazolidin-2-ylidene)ethanone 
• 139057-23-1 [(Z)-1-Methylsulfanyl-3-(4-nitro-phenyl)-3-oxo-propenylamino]-acetic acid 

Relevant academic research and scientific papers

COMPOUNDS FOR INHIBITING TNIK AND MEDICAL USES THEREOF

The present disclosure provides the compound having inhibitory property against TNIK having a specific chemical structure or its pharmaceutically acceptable salt. The present disclosure also provides a composition comprising the compound or its pharmaceutically acceptable salt. The present disclosure also provides a medical use of the compound, its salt or the composition comprising the compound or its pharmaceutically acceptable salt for treating or preventing cancer. The present disclosure also provides a method of treatment or prevention of cancer comprising administering the compound, its salt or the composition comprising the compound or its salt to a subject in need of such treatment or prevention.

Synthesis and molecular docking studies of novel 2-(2-amino-6-phenyl-4-pyrimidinylamino) ethanol derivatives: Using ring-opening reactions of cyclic ketene-N,O-acetal

A series of six novel 2-(2-amino-6-phenyl-4-pyrimidinylamino) ethanol derivatives have been synthesized starting from commercially available substituted acetophenones via Oxoketene Dithioacetals with high yields. Ketene dithioacetal store act with 2-amino

Synthesis and evaluation of antiparasitic activities of new 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine derivatives

A series of new 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine derivatives, prepared by two synthetic routes, were in vitro assayed against three Trypanosoma strains, Leishmania donovani, and Plasmodium falciparum K1. Seven out of 17 compounds showed m

Synthesis and anthelmintic activity of 3-substituted 5-methylthio-isoxazoles

Isoxazole derivatives have been shown to possess antiparasitic activity. In the present study, 3-substituted 5-methylthio-isoxazoles were synthesized and tested for anthelmintic activity, along with some other isoxazoles which have been reported but not t

Infrared Spectra and Theoretical Study of the Conformations of Substituted Benzoylketene-S,S-acetals

The C=O stretching frequencies of substituted benzoylketene-S,S-dimethylacetals (1a-1o) and benzoylketene-S,S-ethyleneacetals (2a-2m) were measured in CHCl3 and CCl4 and correlated with the Hammett substituent constants.The correlations were split into tw

SYNTHESIS OF BENZOYL SUBSTITUTED HETEROCYCLIC KETENE AMINALS BY CONDENSATION OF BENZOYL KETENE MERCAPTALS WITH DIAMINES

2-(Benzoylmethylene)imidazolidines 2 and 5, -hexahydropyrimidines 3 and 6, or -hexahydro-1H-1,3-diazepines 4 were synthesized by the reaction of benzoyl substituted ketene mercaptals 1 with diamines.