81376-88-7 Usage
General Description
Ethanone, 1-(3-ethoxy-2-pyridinyl)- (9CI) is a chemical compound that belongs to the family of ketones and contains a pyridine ring. It is commonly used in the pharmaceutical industry for the synthesis of various drugs and active ingredients due to its unique structure and properties. Ethanone, 1-(3-ethoxy-2-pyridinyl)- (9CI) is known for its potential biological activities, such as antifungal, antimicrobial, and antiparasitic effects. Additionally, it has been studied for its therapeutic potential in treating various diseases and conditions. Overall, Ethanone, 1-(3-ethoxy-2-pyridinyl)- (9CI) is a versatile chemical with promising applications in both research and medicine.
Check Digit Verification of cas no
The CAS Registry Mumber 81376-88-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,3,7 and 6 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 81376-88:
(7*8)+(6*1)+(5*3)+(4*7)+(3*6)+(2*8)+(1*8)=147
147 % 10 = 7
So 81376-88-7 is a valid CAS Registry Number.
81376-88-7Relevant articles and documents
Furopyridines.III.A New Synthesis of Furopyridine
Shiotani, Shunsaku,Morita, Hiroyuki
, p. 665 - 668 (2007/10/02)
A convenient synthesis of furopyridine and its 2- and 3-methyl derivatives from ethyl 3-hydroxypicolinate (1) is described.The hydroxy ester 1 was O-alkylated with ethyl bromoacetate or ethyl 2-bromopropionate to give the diester 2a or 2b.Cyclization of compound 2a afforded ethyl 3-hydroxyfuropyridine-2-carboxylate (3) which in turn was hydrolyzed and decarboxylated to give furopyridin-3-(2H)-one (4a).Cyclization of 2b gave the 2-methyl derivative 4b.Reduction of 4a and 4b with sodium borohydride yielded the corresponding hydroxy derivative 5a and 5b respectively, which were dehydrated with phosphoric acid to give furopyridine (6a) and its 2-methyl derivative (6b). 2-Acetylpyridin-3-ol (8) was converted to the ethoxycarbonylmethyl ether (9) by O-alkylation with ethyl bromoacetate, which was cyclized to give 3-methylfuropyridine-2-carboxylic acid (10).Decarboxylation of 10 afforded 3-methylfuropyridine (11).
