81391-71-1

Upstream product

• 1161-13-3 N-Cbz-L-Phe 
• 60-34-4 methylhydrazine 
• 53665-99-9 Z-Phe-ONB 
• 35909-92-3 N-carbobenzoxy-L-phenylalanine methyl ester 

Downstream Products

• 81378-50-9 {(S)-2-(4-Hydroxy-phenyl)-1-[(R)-1-({[(S)-1-(N'-methyl-hydrazinocarbonyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-ethylcarbamoyl]-ethyl}-carbamic acid benzyl ester 
• 75525-23-4 (S)-2-Amino-3-(4-hydroxy-phenyl)-N-[(R)-1-({[(S)-1-(N'-methyl-hydrazinocarbonyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-ethyl]-propionamide 
• 142182-12-5 1-(N-carbobenzyloxy-L-phenylalanyl)-2-methyl-2-chloroacetyl hydrazine 
• 142182-14-7 1-(N-carbobenzyloxy-L-phenylalanyl)-2-methyl-2-iodoacetyl hydrazine 

Relevant academic research and scientific papers

Azadipeptide nitriles: Highly potent and proteolytically stable inhibitors of papain-like cysteine proteases

(Chemical Presented) Nitrogen instead of carbon: Azadipeptide nitriles resulting from CH/N exchange in the P1 position (see picture) are hitherto unknown. To access these compounds by conversion of amino acid-derived hydrazides with cyanogen bromide both nitrogen atoms of the hydrazide must be substituted. Despite a methylated P2-P1 peptide bond, the azadipeptide nitriles show a strong inhibitory activity against cysteine proteases, and a high stability towards chymotryptic hydrolysis.

1-peptidyl-2-haloacetyl hydrazines as active site directed inhibitors of papain and cathepsin B

Fifteen 1-peptidyl-2-haloacetyl hydrazines, which can be considered halometanes of azapeptides containing Phe in P2 and α-aza-Ala or α-aza-Gly in P1, were synthesized and tested as models of cysteine-proteases inhibitors. By use of k