81403-03-4

Upstream product

• 7157-92-8 4-amino-5-aminocarbonyl-3-phenyl-2,3-dihydro-[1,3]thiazole-2-thione 
• 420-04-2 CYANAMID 
• 103-72-0 phenyl isothiocyanate 
• 107-14-2 chloroacetonitrile 
• 81402-94-0 4-Amino-2-[(Z)-cyanoimino]-3-phenyl-2,3-dihydro-thiazole-5-carboxylic acid amide 

Downstream Products

• 1069114-77-7 9-amino-2-anilino-5,6,7,8-tetrahydro[1,3]-thiazolo[4,5-b]quinoline 
• 1069114-94-8 4-chloro-N-phenyl[1,3]thiazolo[4,5-d][1,2,3]triazine-6-amine 
• 1069114-71-1 8-amino-2-anilino-6,7-dihydro-5H-cyclopenta[b][1,3]-thiazolo[5,4-e]pyridine 
• 1069114-86-8 10-amino-2-anilino-6,7,8,9-tetrahydro5H-cyclohepta[b][1,3]thiazolo[5,4-e]pyridine 

Relevant academic research and scientific papers

Synthesis of substituted [1,3]thiazolo[4,5-b]pyridines and [1,3]thiazolo[4,5-d][1,2,3]triazines

In this work, we described an easy preparation of substituted 4-amino-5-cyano-1,3-thiazoles. These compounds have been used as starting materials to obtain two classes of compounds. New substituted [1,3]thiazolo[4,5-e]pyridines were synthesized in one step via Friedl?nder reaction. Diazotation of 4-amino-5-cyano-1,3-thiazoles afforded 4-chloro[1,3]thiazolo[4,5-d][1,2,3]triazines in one step. The later was substituted by a secondary amine to obtain substituted 4-amino[1,3]thiazolo[4,5-d][1,2,3]triazines.

Use of 2,4-diaminothiazole derivatives

2,4-Diaminothiazole derivatives which inhibit GSK-3 (glycogen synthase kinase-3) and which are useful for the treatment and/or prevention disorders and diseases wherein an inhibition of GSK-3 is beneficial, especially especially Alzheimer's disease, bipolar disorder, IGT (impaired glucose tolerance), Type 1 diabetes, Type 2 diabetes and obesity.

On the Chemistry of 4-Aminothiazoline-2-thiones

4-Aminothiazolin-2-one-hydrazones 3 are obtained by succesive treatment of the title compound 1 with dimethyl sulfate and hydrazinehydrate.The rearrangement of 4-aminothiazolin-2-ylidenmalononitrile 7 derived from 1 yields the 2,4-diamino-thiophene deriva