81416-56-0

Basic information

• Product Name: 3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-2-phenyl-4-(sulfooxy)-
• CAS NO: 81416-56-0
• Molecular Formula: C11H12N2O5S
• Molecular Weight: 284.293
• Mol File: 81416-56-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-2-phenyl-4-(sulfooxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-2-phenyl-4-(sulfooxy)-(81416-56-0)
• EPA Substance Registry System: 3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-2-phenyl-4-(sulfooxy)-(81416-56-0)

Safety Data

• Hazardous Substances Data: 81416-56-0(Hazardous Substances Data)

Upstream product

• 1672-63-5 4-hydroxyantipyrine 

Relevant articles and documents

Effects of 4-hydroxyantipyrine and its 4-O-sulfate on antipyrine as biodistribution promoter

The effects of 4-hydroxyantipyrine (4-OH), a major metabolite of antipyrine, and its 4-O-sulfate (4-S) on the pharmacokinetics of antipyrine were investigated in rats. Plasma elimination of intravenously administered antipyrine was significantly decelerated under a steady-state concentration of 4-OH but not under that of 4-S. Tissue-to-plasma concentration ratio (Kp) of antipyrine under its steady-state concentration was significantly increased in the brain and heart by the concomitant use of 4-OH, while similar use of 4-S had no effect. The enhancement of the blood-brain barrier (BBB) permeability of antipyrine caused by the concomitant use of 4-OH was believed to be concerned with the increase of the Kp value of antipyrine in the brain. These results suggested that 4-OH could be used as a biodistribution promoter.