1672-63-5

Basic information

• Product Name: 4-HYDROXYANTIPYRINE
• Synonyms: 4-HYDROXYANTIPYRINE;4-HYDROXY-2,3-DIMETHYL-1-PHENYL-3-PYRAZOLIN-5-ONE;1,5-Dimethyl-2-phenyl-4-hydroxy-4-pyrazoline-3-one;2,3-Dihydro-4-hydroxy-1,5-dimethyl-2-phenyl-1H-pyrazol-3-one;4-hydroxy-1,5-dimethyl-2-phenyl-pyrazol-3-one;4-hydroxy-1,5-dimethyl-2-phenylpyrazol-3-one;NSC 174055
• CAS NO: 1672-63-5
• Molecular Formula: C₁₁H₁₂N₂O₂
• Molecular Weight: 204.23
• Product Categories: Heterocyclic Compounds
• Mol File: 1672-63-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 184-186 °C(lit.)
• Boiling Point: 314.3°Cat760mmHg
• Flash Point: 143.9°C
• Appearance: /
• Density: 1.294g/cm³
• Vapor Pressure: 0.000199mmHg at 25°C
• Refractive Index: 1.63
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 11.99±0.20(Predicted)
• CAS DataBase Reference: 4-HYDROXYANTIPYRINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXYANTIPYRINE(1672-63-5)
• EPA Substance Registry System: 4-HYDROXYANTIPYRINE(1672-63-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 1672-63-5(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 1672-63-5 differently. You can refer to the following data:
1. Antipyrine metabolite
2. 4-Hydroxyantipyrine is a metabolite of antipyrine (A697500) which is an analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver.
3. 4-Hydroxyantipyrine was used to study the relationships between the metabolism of antipyrine, hexobarbitone and theophylline in man. It was used in a study on flow injection analysis system for the characterisation of pharmaceutical compounds via combination of diode array UV, 1H NMR, FT-IR spectroscopy and time-of-flight mass spectrometry.

General Description

4-Hydroxyantipyrine is formed during oxidative deamination of aminopyrine. It is a metabolite of antipyrine.

InChI:InChI=1/C11H12N2O2/c1-8-10(14)11(15)13(12(8)2)9-6-4-3-5-7-9/h3-7,14H,1-2H3

Upstream product

• 60-80-0 antipyrine 
• 7732-18-5 water 
• 50-81-7 ascorbic acid 
• 68-89-3 metamizol 
• 6536-18-1 Morazone 
• 2139-47-1 nifenazone 
• 3615-24-5 ramifenazone 
• 58-15-1 aminopyrine 
• 479-92-5 propyphenazone 
• 5426-65-3 4-bromoantipyrine 
• 83-07-8 4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one 
• 74-88-4 methyl iodide 

Downstream Products

• 100615-46-1 4-ethoxy-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one 
• 23097-55-4 methoxy-4 antipyrine 
• 123777-28-6 4,4'-bis-benzyloxy-1,1'-dimethyl-2,2'-diphenyl-1,2,1',2'-tetrahydro-5,5'-ethanediyl-bis-pyrazol-3-one 
• 103032-43-5 4,4'-diacetoxy-1,1'-dimethyl-2,2'-diphenyl-1,2,1',2'-tetrahydro-5,5'-ethanediyl-bis-pyrazol-3-one 
• 76788-81-3 Bernsteinsaeure 
• 28070-40-8 4-Hydroxy-antipyrine β-D-glucuronide 
• 81416-56-0 4-Hydroxyantipyrine Sulfate 
• 76788-80-2 Bis(4,4'-hydroxyphenazon) 
• 38604-70-5 1-acetyl-1-methyl-2-phenylhydrazine 
• 144-62-7 oxalic acid 
• 38988-02-2 Oxalsaeure-mono(2-acetyl-2-methyl-1-phenyl)hydrazid 
• 620-81-5 N,N'-Diphenyloxamid 
• 10605-18-2 N-Methyl-N-phenyl oxamide 
• 88741-26-8 6-Methyl-2-<1-(methylimino)ethyl>-4-oxohepta-2,5-dienoic anilide 

Related news

Assay of antipyrine and its main metabolites 3-hydroxymethylantipyrine, norantipyrine and 4-HYDROXYANTIPYRINE (cas 1672-63-5) in urine☆09/25/2019

Two assay methods for antipyrine (AP) and its main metabolites 3-hydroxymethylantipyrine (3-HMA), norantipyrine (NORA) and 4-hydroxyantipyrine (4-HA) in urine samples have been compared. Method I involved a 3 h incubation at 37°C with β-glucuronidase, whereas method II used acid hydrolysis wit...detailed

Separation and identification of the 4-HYDROXYANTIPYRINE (cas 1672-63-5) sulphoconjugate09/24/2019

In a previous study we observed, during separation of total antipyrine metabolites by high-performance liquid chromatography and after enzymatic hydrolysis, an unidentified peak corresponding to an ionic compound with pyrazolinone features. In the present study, this compound was identified as t...detailed

Relevant articles and documents

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Photochemical decomposition of phenazone derivatives. Part 7: Mechanism of decomposition in aqueous solutions

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Stability of phenazone

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