81437-83-4

Upstream product

• 83-07-8 4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one 
• 105-56-6 ethyl 2-cyanoacetate 
• 61341-50-2 4-amino-1-methyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one 

Downstream Products

• 82315-73-9 4-{N'-[3-Amino-5-hydroxy-pyrazol-(4E)-ylidene]-hydrazino}-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one 
• 82315-76-2 7-Imino-1,7a-dimethyl-3-oxo-2-phenyl-2,3,7,7a-tetrahydro-1H-pyrazolo[4,3-c]pyridazine-6-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Design, synthesis, and in vitro anticancer screening of novel pyrazolinyl-pyrazole/1, 2, 3-triazole hybrids

Novel hybrids, pyrazolinylpyrazoles, and pyrazolinyltriazoles were designed, synthesized, and screened for their anticancer activity. Eleven compounds were selected by the National Cancer Institute (NCI)/USA for anticancer screening at single high dose (10?5 M) in full NCI 60 cell panels. Two compounds: 4-aminopyrazole-5-carbonitrile, 5c (NSC-747630/1) and ethyl 4-aminopyrazole-5- carboxylate, 7d (NSC-747634/1) were the most active candidates of the series and were selected for further evaluation at five dose screening as they displayed significant growth inhibition with full panel median growth inhibition (GI50) 5.47 and 2.24 μM, respectively. Both 5c and 7d hybrids exhibited broad spectrum antitumor activity; however 7d showed moderate selectivity (selectivity ratio 3.6) toward leukemia.

Pyrazoles and Isoxazoles Based Sulfanilamide and Phenazone as Antimicrobial Agents: Synthesis and Biological Activity

New pyrazole and pyridine derivatives have been synthesized from sulfanilamide and phenazone via diazotization and coupling with a wide range of α-CH acids followed by heterocyclization with hydrazine derivative, hydroxylamine and cyanoacetamide. The anti

Novel pyrazole derivatives as anticancer and radiosensitizing agents

The present article describes the synthesis of some novel pyrrole, pyrazolo[4,3-d]oxazole, pyrrolo[2,3-b]pyridine, 1,2,3-triazole and oxoazetidin derivatives incorporating pyrazole moiety, the structures of which were confirmed by elemental analyses and s

Reactions with Heterocyclic Diazonium Salts: Novel Synthesis of Pyrazolopyridazines and of Pyrazolopyrazoles

Diazotised 4-amino-1,5-dimethyl-2-phenylpyrazol-3(2H)-one (1) coupled with active methylene nitriles to yield the corresponding cyanohydrazones (3a-c) and (11).Compounds (3a-c) afforded the 4-(3-aminopyrazol-4-ylidenehydrazino)-1,5-dimethyl-2-phenylpyrazo