81454-76-4Relevant academic research and scientific papers
Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides
Marson, Charles M.,Savy, Pascal,Rioja, Alphonse S.,Mahadevan, Thevaki,Mikol, Catherine,Veerupillai, Arthi,Nsubuga, Eva,Chahwan, Angela,Joel, Simon P.
, p. 800 - 805 (2007/10/03)
The synthesis of a novel series of potent inhibitors of histone deacetylases is described, based on arylsulfinyl-2,4-hexadienoic acid hydroxyamicles and their derivatives. In vitro IC50 values clown to 40 nM were obtained, and several compounds showed inhibition of CEM (human leukemic) cell viability with IC50 of ～1.5 μM, comparable to or better than that of suberoylatiilide hydroxamic acid, an inhibitor of histone cleacetylase currently in clinical trials.
HISTONE DEACETYLASE INHIBITORS
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, (2008/06/13)
The present invention provides histone deacetylase inhibitors of general formula (I), process for the preparation of such compounds and uses of the compounds in medicine.
On the Preparation and Rearrangement of Some Vinylic Sulphoxides
Cass, Quezia B.,Jaxa-Chamiec, Albert A.,Kunec, Ellen K.,Sammes, Peter G.
, p. 2683 - 2686 (2007/10/02)
The condensation of methyl benzenesulphinylacetate 1 with a series of aldehydes has been explored using different catalysts.With zinc chloride, the enolate of 1 produces the conjugated ester directly.A base-catalysed rearrangement of these conjugated este
Preparation and Rearrangement of Some Conjugated Phenylsulphinylacetate Derivatives
Cass, Quezia B.,Jaxa-Chamiec, Albert A.,Sammes, Peter G.
, p. 1248 - 1250 (2007/10/02)
The direct condensation of saturated or unsaturated aldehydes with methyl phenylsulphinylacetate can be effected with the products undergoing base-catalysed rearrangements, those from saturated aldehydes yielding γ-hydroxy-αβ-unsaturated esters, whilst crotonaldehyde gives rise to methyl 6-phenylsulphinylhexa-2,4-dienoate.
