81465-82-9

Basic information

• Product Name: 5-AMINO-3-(4-FLUOROPHENYL)ISOXAZOLE
• Synonyms: 5-Amino-3-(4-fluorophenyl)isoxazole 98%;3-(4-FLUOROPHENYL)-5-ISOXAZOLAMINE;5-Amino-3-(4-fluorophenyl)isoxazole98%;3-(4-Fluorophenyl)-1,2-oxazol-5-amine
• CAS NO: 81465-82-9
• Molecular Formula: C₉H₇FN₂O
• Molecular Weight: 178.17
• Mol File: 81465-82-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 102 °C
• Boiling Point: 373.7°C at 760 mmHg
• Flash Point: 179.8°C
• Appearance: /
• Density: 1.298g/cm³
• Vapor Pressure: 8.77E-06mmHg at 25°C
• Refractive Index: 1.576
• Storage Temp.: 2-8°C(protect from light)
• Sensitive: Light Sensitive
• CAS DataBase Reference: 5-AMINO-3-(4-FLUOROPHENYL)ISOXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-3-(4-FLUOROPHENYL)ISOXAZOLE(81465-82-9)
• EPA Substance Registry System: 5-AMINO-3-(4-FLUOROPHENYL)ISOXAZOLE(81465-82-9)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 81465-82-9(Hazardous Substances Data)

Usage

General Description

5-Amino-3-(4-fluorophenyl)isoxazole is a chemical compound containing an isoxazole ring with an amino group and a 4-fluorophenyl substituent. It is a heterocyclic aromatic compound that may have potential pharmaceutical applications due to its structure. Its properties and potential uses may be further explored in medicinal chemistry and drug development.

InChI:InChI=1/C9H7FN2O/c10-7-3-1-6(2-4-7)8-5-9(11)13-12-8/h1-5H,11H2

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Relevant articles and documents

An enantioselective aza-Friedel-Crafts reaction of 5-aminoisoxazoles with isatin-derived: N -Boc ketimines

By employing a chiral phosphoric acid as a catalyst, an enantioselective aza-Friedel-Crafts reaction of 5-aminoisoxazoles with isatin-derived N-Boc ketimines was realized. The reaction provided a wide variety of novel 3-isoxazole 3-amino-oxindoles with good yields (up to 99%) and moderate to good enantioselectivities (up to 99%). The absolute configuration of one product was assigned by X-ray crystal structural analysis and a plausible reaction mechanism was proposed. In addition, a scale-up reaction was performed successfully. Finally, one product was subjected to Suzuki-Miyaura coupling with phenylboronic acid to afford the product in a moderate yield without erosion of the enantioselectivity. This journal is

Hoveyda-Grubbs II Catalyst: A Useful Catalyst for One-Pot Visible-Light-Promoted Ring Contraction and Olefin Metathesis Reactions

A one-pot reaction to synthesize functionalized 2H-azirines through visible-light-mediated ring contraction and olefin metathesis of isoxazoles is described. Hoveyda-Grubbs II catalyst was found to function as a photocatalyst for these transformations, al

1-Benzoyl-3-(isoxazolyl or benzisoxazolyl)-ureas and insecticidal use thereof

The present invention is directed to 1-(benzoyl)-3-(isoxazolyl or benzisoxazolyl)urea or thiourea compounds useful as insecticides.