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81467-07-4

Thiourea, N-cyclohexyl-N'-(2-hydroxyethyl)- is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 81467-07-4 Structure

  • Basic information

    1. Product Name: Thiourea, N-cyclohexyl-N'-(2-hydroxyethyl)-
    2. Synonyms:
    3. CAS NO:81467-07-4
    4. Molecular Formula: C9H18N2OS
    5. Molecular Weight: 202.321
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 81467-07-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Thiourea, N-cyclohexyl-N'-(2-hydroxyethyl)-(CAS DataBase Reference)
    10. NIST Chemistry Reference: Thiourea, N-cyclohexyl-N'-(2-hydroxyethyl)-(81467-07-4)
    11. EPA Substance Registry System: Thiourea, N-cyclohexyl-N'-(2-hydroxyethyl)-(81467-07-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 81467-07-4(Hazardous Substances Data)

81467-07-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 81467-07-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,4,6 and 7 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 81467-07:
(7*8)+(6*1)+(5*4)+(4*6)+(3*7)+(2*0)+(1*7)=134
134 % 10 = 4
So 81467-07-4 is a valid CAS Registry Number.

81467-07-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-cyclohexyl-3-(2-hydroxyethyl)thiourea

1.2 Other means of identification

Product number -
Other names 1-Cyclohexyl-3-(2-hydroxy-ethyl)-thiourea

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:81467-07-4 SDS

81467-07-4Relevant articles and documents

New 2-Aminothiazoline derivatives lower blood pressure of spontaneously hypertensive rats (SHR) via I1-imidazoline and alpha-2 adrenergic receptors activation

Ferreira, Renan B.,de Oliveira, Mariana G.,Antunes, Edson,Almeida, Wanda P.,Ibrahim, Badr M.,Abdel-Rahman, Abdel A.

, p. 803 - 810 (2016/11/09)

2-Aminothiazolines share an isosteric relationship with imidazolines and oxazolines with antihypertensive activity mainly mediated by the imidazoline I1-receptor. In the present work, we have prepared five aminothiazolines, following a previously described synthetic pathway. Aminothiazolines derived from dicyclopropylmethylamine (ATZ1) and cyclohexylamine (3) are unprecedented in the literature. Competitive radioligand assay was carried out with all synthetic compounds, and the I1receptor affinity in comparison to rilmenidine in PC12 cells was determined. Surprisingly, the rilmenidine isoster (ATZ1) showed no I1-receptor interaction. Diethyl (ATZ4) and 2-ethyl-hexylamine (ATZ5) derivatives bind to the receptor with 11.98 and 10.94 nmol/l, respectively. These compounds were selected for in vivo experiments. Both compounds reduced the blood pressure of spontaneously hypertensive rats (SHR). The hypotensive effect of these compounds was abrogated in the presence of α2adrenergic (yohimbine) and I1(efaroxan) receptor antagonists suggesting that both aminothiazolines bind to the adrenergic and imidazoline receptors. Lipinski's descriptors of the synthesized aminothiazolines were calculated and are similar to the known imidazoline I1receptor ligands. 3D-Similarity between ATZ5 and agmatine, the natural imidazoline receptor ligand, was also observed.

(2-hydroxy)ethyl-thioureas useful as modulators of alpha2B adrenergic receptors

-

, (2008/06/13)

Compounds of formula (i) and of formula (ii) wherein the symbols have the meaning disclosed in the specification, specifically or selectively modulate α2B and/or α2C adrenergic receptors in preference over α2A adrenergic receptors, and as such are useful for alleviating chronic pain and allodynia and have no or only minimal cardivascular and/or sedatory activity.

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