81467-58-5

Upstream product

• 201230-82-2 carbon monoxide 
• 1250259-31-4 N-(4-methoxybenzyl)-N-isopropylpropan-2-amine 
• 104-01-8 4-Methoxyphenylacetic acid 
• 108-18-9 diisopropylamine 
• 4693-91-8 4-methoxyphenyl-acetic chloride 

Downstream Products

• 683766-48-5 N,N-diisopropyl-2-(4-methoxyphenyl)propanamide 

Relevant academic research and scientific papers

Charge-Transfer Complex Promoted C-N Bond Activation for Ni-Catalyzed Carbonylation

A new strategy was developed for activation of C-N bond via formation of an amine-I2 charge-transfer complex, which facilitates the inert C-N bond activation via oxidative addition with Ni(0). This strategy has been successfully applied in the Ni-catalyzed carbonylation of benzylamines via direct insertion of CO into the C-N bond, which provided a straightforward and rapid approach to arylacetamides in the presence of catalytic amounts of I2 and Ni catalyst. Mechanistic studies suggested that a benzyl radical generated via the oxidative addition was involved in the present reaction.

Palladium-Catalyzed Synthesis of 3-Trifluoromethyl-Substituted 1,3-Butadienes by Means of Directed C-H Bond Functionalization

A palladium-catalyzed C-H bond functionalization of acrylamides was developed to build up stereoselectively trifluoromethylated 1,3-butadienes. Using a tertiary amide as a directing group, olefins were selectively functionalized with 2-bromo-3,3,3-trifluoropropene to access these important fluorinated compounds. The methodology was extended to the construction of pentafluoroethyl-substituted 1,3-dienes. Mechanistic studies supported by density functional theory calculations suggested a redox neutral mechanism for this transformation.

The synthesis and characterisation of deuteriated amides

Results are reported on the regioselective C-deuteriation of a series of enolates derived from the addition of sec-BuLi to a variety of substituted amides. The outcomes of the reactions are discussed in terms of the structural nature of the amides and the