1250259-31-4Relevant academic research and scientific papers
Controlled Reduction of Carboxamides to Alcohols or Amines by Zinc Hydrides
Ong, Derek Yiren,Yen, Zhihao,Yoshii, Asami,Revillo Imbernon, Julia,Takita, Ryo,Chiba, Shunsuke
supporting information, p. 4992 - 4997 (2019/03/13)
New protocols for controlled reduction of carboxamides to either alcohols or amines were established using a combination of sodium hydride (NaH) and zinc halides (ZnX2). Use of a different halide on ZnX2 dictates the selectivity, wherein the NaH-ZnI2 system delivers alcohols and NaH-ZnCl2 gives amines. Extensive mechanistic studies by experimental and theoretical approaches imply that polymeric zinc hydride (ZnH2)∞ is responsible for alcohol formation, whereas dimeric zinc chloride hydride (H?Zn?Cl)2 is the key species for the production of amines.
Preparation of Aldehydes by Oxidation of Benzylic Amines with Selectfluor (F-TEDA-BF4)
Hauser, Anett,Bohlmann, Rolf
supporting information, p. 1870 - 1872 (2016/07/16)
Aldehydes are obtained by mild oxidation of benzylic amines with Selectfluor. The results are compared favorably with the Polonovski-like process using hypervalent iodine.
Amide activation by Tf2O: Reduction of amides to amines by NaBH4 under mild conditions
Xiang, Shao-Hua,Xu, Jian,Yuan, Hong-Qiu,Huang, Pei-Qiang
supporting information; experimental part, p. 1829 - 1832 (2010/10/02)
An expeditious and practical method for the reduction of amides to amines is reported. The method is consisted of activation of amides with Tf 2O followed by reduction with sodium borohydride in THF at room temperature. Various amides/lactams gave the corresponding amines in good to excellent yields, even with hindered amides and secondary amides. This method also presents other advantages such as TBDPS-group tolerance, short reaction time, simple workup and purification procedure. Georg Thieme Verlag Stuttgart.
