81479-19-8Relevant academic research and scientific papers
Optically active imidazolidin-2-one derivatives
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, (2008/06/13)
A novel optically active cis-4,5-disubstituted imidazolidin-2-one derivative of the formula: STR1 wherein R1 is a C1 -C4 alkyl group or benzyl and R2 is a chiral aralkyl group optionally having at least one of C1 -C4 alkyl, C1 -C4 alkoxy and hydroxyl groups is produced asymmetrically by the reaction of 1,3-dibenzyl-cis-4,5-dicarboxy-imidazolidin-2-one or its anhydride with an optically active secondary amine of the formula: STR2 wherein R1 and R2 are each as defined above and is transformed into the lactone of 1,3-dibenzyl-cis-4-carboxy-5-hydroxymethyl-imidazolidin-2-one, which is a key intermediate in the synthesis of d-biotin.
