16735-30-1

Usage

Uses

Used in Research and Scientific Experiments:
2-(Benzyl methyl amino)-1-phenylpropan-1-one is used as a research chemical for conducting various scientific experiments and studies. Its unique chemical properties make it valuable in exploring new chemical reactions and understanding its behavior in different conditions.
Used in Pharmaceutical and Medical Industries:
2-(Benzyl methyl amino)-1-phenylpropan-1-one is used as a potential active pharmaceutical ingredient or intermediate in the development of new drugs. Its specific chemical structure may offer therapeutic benefits in treating certain medical conditions, although further research is required to fully understand its potential applications and efficacy.

Upstream product

• 2114-00-3 2-bromo-1-phenyl-1-propanone 
• 103-67-3 benzyl-methyl-amine 
• 93-55-0 1-phenyl-propan-1-one 
• 6084-17-9 2-chloro-1-phenylpropan-1-one 
• 37471-46-8 1-phenyl-1-trimethylsiloxypropene 

Downstream Products

• 90-81-3 ephedrine 
• 90-85-7 (+/-)-erythro-2-(methyl-benzyl-amino)-1-phenyl-propanol-⁽¹⁾ 
• 5650-44-2 methcathinone 
• 90-85-7 (1RS,2RS)-2-(benzyl-methyl-amino)-1-phenyl-propan-1-ol 
• 159099-80-6 (1S,2S)-2-(N-benzyl-N-methylamino)-1-phenyl-1-propanol 
• 537-46-2 Methamphetamin 
• 299-42-3 ephedrine 
• 90-82-4 pseudoephedrine 
• 52340-16-6 (1R,2S)-1-cyclohexyl-2-methylamino-propan-1-ol 
• 5650-44-2 (-)-Methcathinone 
• 160977-88-8 (+)-Methcathinone 
• 73081-72-8 1,3,5-trimethyl-4-phenyl-1,5-dihydro-2-pyrrolone 
• 877869-98-2 3-butyl-1,5-dimethyl-4-phenyl-1,5-dihydro-2-pyrrolone 
• 877869-97-1 3-isopropyl-1,5-dimethyl-4-phenyl-1,5-dihydro-2-pyrrolone 

Relevant academic research and scientific papers

Electrochemically Oxidative α-C-H Functionalization of Ketones: A Cascade Synthesis of α-Amino Ketones Mediated by NH4I

An efficient electrochemical protocol for the synthesis of α-amino ketones via the oxidative cross-dehydrogenative coupling of ketones and secondary amines has been developed. The electrochemistry performs in a simple undivided cell using NH4I

Electrochemical, Iodine-Mediated α-CH Amination of Ketones by Umpolung of Silyl Enol Ethers

The electrochemical, oxidative Umpolung reaction of silyl enol ethers utilizing simple iodide salts for the synthesis of α-amino ketones is described. The products were isolated in excellent yields of up to 100percent, and various functionalized starting materials were accepted in an undivided electrochemical cell design. Moreover, a sensitivity assessment to ensure an improved reproducibility of the reaction and cyclic voltammetry experiments were performed to postulate a plausible reaction mechanism on their basis.

Transition-metal-free oxidative α-C-H amination of ketones via a radical mechanism: Mild synthesis of α-amino ketones

A transition-metal-free direct α-C.H amination of ketones has been developed using commercially available ammonium iodide as the catalyst and sodium percarbonate as the co-oxidant. A wide range of ketone ((hetero)aromatic or nonaromatic ketones) and amine (primary/secondary amines, anilines, or amides) substrates undergo cross-coupling to generate synthetically useful α-amino ketones. The mechanistic studies indicated that a radical pathway might be involved in the reaction process. The utility of the method is highlighted through a concise one-step synthesis of the pharmaceutical agent amfepramone.

Heteroatom-guided torquoselective olefination of α-oxy and α-amino ketones via ynolates

Ynolates were found to react with α-alkoxy-, α-siloxy-, and α -aryloxyketones at room temperature to afford tetrasubstituted olefins with high Z selectivity. Since the geometrical selectivity was determined in the ring opening of the β-lactone enolate intermediates, the torquoselectivity was controlled by the ethereal oxygen atoms. From experimental and theoretical studies, the high Z selectivity is in duced by orbital and steric interactions rather than by chelation. In a similar manner, α-dialkylamino ketones provided olefins with excellent Z selectivity. These products can be easily converted into multisubstituted butenolides and γ-butyrolactams in good yield.