81482-71-5

Upstream product

• 870-46-2 t-butoxycarbonylhydrazine 
• 81482-46-4 benzhydryl 7-oxo-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylate 

Downstream Products

• 81482-81-7 (6R,7R)-7-(N'-tert-Butoxycarbonyl-hydrazino)-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 82975-17-5 (6R,7R)-7-[N'-tert-Butoxycarbonyl-N-(2-thiophen-2-yl-acetyl)-hydrazino]-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 

Relevant academic research and scientific papers

Method of producing oxo-containing azetidinone compounds

This invention relates to a novel method of producing oxo-containing azetidinone compounds, or salts thereof, or hydrates thereof, said compounds having utility as antimicrobial agents and as intermediates for the synthesis of other azetidinone compounds having antimicrobial activity.

SYNTHESIS OF 7-HYDRAZINOCEPHALOSPORINS

Hydrazonation of 7-oxocephems 2a,b, followed by borane reduction of the resulting E and Z hydrazono compounds 3a,b and 4a,b, provided the key intermediates 5a,b, which were acylated to 6a,b and then deprotected to yield the 7-hydrazinocephalosporin deriva