81484-33-5Relevant academic research and scientific papers
CF3-BOP, CF3-PyBOP and CF3-HBTU: New peptide coupling reagents specially suited for α-aminoisobutyric acid condensations
Wijkmans, Jac C. H. M.,Kruijtzer, John A. W.,Marel, Gijs A. van der,Boom, Jacques H. van,Bloemhoff, Wim
, p. 394 - 397 (1994)
The peptide-coupling reagents CF3-BOP (1b), CF3-PyBOP (1c) and CF3-HBTU (2a) with built-in 1-hydroxy-6-(trifluoromethyl)benzotriazole proved to be highly efficient for the coupling of α-aminoisobutyric acid residues.
PyBOP and PyBroP: Two reagents for the difficult coupling of the α,α-dialkyl amino acid, Aib
Frerot, Eric,Coste, Jacques,Pantaloni, Antoine,Dufour, Marie-Noelle,Jouin, Patrick
, p. 259 - 270 (2007/10/02)
The difficult coupling of α-aminoisobutyric acid (Aib) was carried out using PyBOP and PyBroP in a comparative study with BOP and BroP. These reagents gave good results under simple conditions (one pot, r.t., 1h). Coded amino acids could be coupled with Aib using PyBOP under standard conditions of peptide synthesis without racemization whereas the coupling of two Aib residues required PyBroP/DMAP. A fragment containing an Aib C-terminal could be coupled without epimerization of the penultimate residue.
