815-03-2

Upstream product

• 82817-12-7 2,2,2-Trifluoro-O-(trifluoroacetyl)acetohydroximoyl Chloride 

Downstream Products

• 82986-02-5 S-Phenyl (Z)-2,2,2-trifluoro-N-hydroxythioacetimidate 
• 88326-78-7 S-Benzyl (Z)-2,2,2-Trifluoro-N-hydroxythioacetimidate 
• 62847-45-4 5-phenyl-3-(trifluoromethyl)isoxazole 
• 4314-35-6 2,2,2-trifluoro-N'-hydroxyacetimidamide 

Relevant academic research and scientific papers

Trifluoroacetonitrile Oxide

Trifluoroacetonitrile oxide (1) is a reactive intermediate that can be generated by the dehydrochlorination of trifluoroacetohydroximoyl chloride (2) with base.It reacts with mercaptans and amines in a stereospecific manner to give Z oximes 3 and 15 and forms a cycloadduct (10) with benzonitrile.In the absence of trapping agents, it dimerizes to give either the expected furoxan dimer 7 or the unusual dioxadiazine dimer 8, depending upon conditions.A convenient synthesis for 2 based on hydroxylamine hydrochloride, trifluoroacetic anhydride, and PCl3 was developedto make 1 easily accessible.