81512-06-3Relevant academic research and scientific papers
Eco-friendly synthesis of α-aminonitriles from ketones in PEG-400 medium using potassium Hexacyanoferrate(II) as cyanide source
Hu, Xiaochun,Ma, Yuanhong,Li, Zheng
, p. 70 - 74 (2012)
An efficient method for the synthesis of α-aminonitriles via one-pot three-component condensation of ketones, amines and potassium hexacyanoferrate(II) using benzoyl chloride as a promoter and PEG-400 as a reaction medium was described. This protocol has
Magnetic solid sulfonic acid decorated with hydrophobic regulators: A combinatorial and magnetically separable catalyst for the synthesis of α-aminonitriles
Mobaraki, Akbar,Movassagh, Barahman,Karimi, Babak
supporting information, p. 352 - 358 (2014/08/05)
A three-component, Strecker reaction of a series of aldehydes or ketones, amines, and trimethylsilyl cyanide for the synthesis of α-aminonitriles in the presence of a catalytic amount of a magnetic solid sulfonic acid catalyst, Fe3O4@SiO2@Me&Et-PhSO3H under solvent-free conditions have been investigated. This catalyst, with a combination of hydrophobicity and acidity on the Fe3O 4@SiO2 core-shell of the magnetic nanobeads, as well as its water-resistant property, enabled easy mass transfer and catalytic activity in the Strecker reaction. The catalyst was easily separated by an external magnet and the recovered catalyst was reused in 6 successive reaction cycles without any significant loss of activity.
