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2-(CHLOROMETHYL)-7-METHYL-5H-[1,3,4]THIADIAZOLO[3,2-A]PYRIMIDIN-5-ONE is a heterocyclic compound synthesized through the reaction of chloromethyl methyl ether with amino guanylhydrazone. It is of interest due to its electron-deficient heteroaromatic ring, which is known to exhibit various biological activities such as anti-inflammatory, antimicrobial, and anticancer properties. Its unique structure makes it a potential candidate for drug development and medicinal chemistry research.

81516-46-3

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81516-46-3 Usage

Uses

Used in Pharmaceutical Industry:
2-(CHLOROMETHYL)-7-METHYL-5H-[1,3,4]THIADIAZOLO[3,2-A]PYRIMIDIN-5-ONE is used as a potential drug candidate for its anti-inflammatory, antimicrobial, and anticancer properties. Its electron-deficient heteroaromatic ring contributes to these biological activities, making it a promising compound for further research and development in the pharmaceutical field.
Used in Medicinal Chemistry Research:
2-(CHLOROMETHYL)-7-METHYL-5H-[1,3,4]THIADIAZOLO[3,2-A]PYRIMIDIN-5-ONE is used as a subject of study in medicinal chemistry research to explore its potential pharmacological properties and applications. Its unique structure and electron-deficient heteroaromatic ring offer opportunities for the development of new therapeutic agents and a deeper understanding of its biological activities.

Check Digit Verification of cas no

The CAS Registry Mumber 81516-46-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,5,1 and 6 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 81516-46:
(7*8)+(6*1)+(5*5)+(4*1)+(3*6)+(2*4)+(1*6)=123
123 % 10 = 3
So 81516-46-3 is a valid CAS Registry Number.

81516-46-3Downstream Products

81516-46-3Relevant academic research and scientific papers

Some transformations of 2-chloromethyl-7-methyl-5H-1,3,4-thiadiazolopyrimidin-5-one

Shukurov, V. I.,Kukaniev, M. A.,Nasyrov, M. I.,Zakharov, K. S.,Karakhanov, R. A.

, p. 854 - 856 (1994)

The reactions of 2-chloromethyl-7-methyl-5H-1,3,4-thiadiazolopyrimidin-5-one with tert-butyl hypochlorite and molecular bromine and the replacement of the chlorine atom in the chloromethyl group through the action of piperidine and morpholine were investigated. - Key words: electrophilic and nucleophilic substitution; 2-chloromethyl-7-methyl-5H-1,3,4-thiadiazolopyrimidin-5-one; tert-butyl hypochlorite; molecular bromine; piperidine; morpholine.

Convenient Synthesis of 2,7-Disubstituted 5H-1,3,4-Thiadiazolopyrimidin-5-ones and Related Compounds

Tsuji, Tadakazu,Takenaka, Keiko

, p. 637 - 638 (2007/10/02)

2,7-Disubstituted 5H-1,3,4-thiadiazolopyrimidin-5-ones were synthesized from the reaction of 3-amino-6-methyl-2-thiouracil with carboxylic acid or from that of thiosemicarbazide with carboxylic acid and β-keto ester in the presence of phosphorus pentaoxide and methanesulfonic acid.The synthesis of related compounds is also described.

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