81528-48-5

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 4-aMino-5-Methylthiophene-3-carboxylate is used as an intermediate in the synthesis of various pharmaceutical compounds for its diverse properties and potential applications in medicine.
Used in Antimicrobial Applications:
Methyl 4-aMino-5-Methylthiophene-3-carboxylate is used as an antimicrobial agent for its potential to combat various types of infections due to its biological activity.
Used in Antifungal Applications:
Methyl 4-aMino-5-Methylthiophene-3-carboxylate is used as an antifungal agent to treat fungal infections, leveraging its inherent biological properties.
Used in Anticancer Applications:
Methyl 4-aMino-5-Methylthiophene-3-carboxylate is used as an anticancer agent, being the subject of research for its potential to inhibit cancer cell growth and contribute to cancer treatment.
Due to its reactivity and potential hazards, Methyl 4-aMino-5-Methylthiophene-3-carboxylate is typically stored and handled under controlled conditions, ensuring safety in its applications across different fields of medicine.

Upstream product

• 66319-07-1 5-methyl-4-oxotetrahydro-3-thiophencarboxylic acid methyl ester 
• 66319-01-5 methyl 4-(hydroxyimino)-5-methyltetrahydrothiophen-3-carboxylate 
• 66319-05-9 2-<(2-Methoxycarbonyl)ethylthio>propionsaeure-ethylester 

Downstream Products

• 317815-94-4 methyl 4-(chlorosulfonyl)-5-methylthiophene-3-carboxylate 
• 172889-34-8 4-acetylamino-5-methylthiophen-3-methanol 

Relevant academic research and scientific papers

METHOD FOR THE PRODUCTION OF SUBSTITUTED 2-ALKOXYCARBONYL-3-AMINOTHIOPHENES

The invention relates to a method for producing 4-alkoxycarbonyl-3-aminothiophenes of general formula (I) and/or the hydrochlorides thereof of formula (I)', wherein R1 and R2 have the meaning indicated in the description, and the monoacetylated or diacetylated or the monoformylated or diformylated form thereof by reacting enamines of formula (Il), wherein R1 and R2 have the meaning indicated in the description, and/or the monoacetylated or diacetylated or the monoformylated or diformylated form thereof with a chlorinating agent in the presence of one or several thinners. Also disclosed is a method for producing the compounds of formula (II).

Substituted thien-3-yl-sulphonylamino(thio)carbonyl-triazolin(ethi)ones

The invention relates to novel substituted thien-3-yl-sulphonylamino(thio)carbonyl-triazolin(ethi)ones of the general formula (I) in which Q1, Q2, R1, R2, R3 and R4 are each as defined in the description, and to salts of the compounds according to formula (I), to processes and to novel intermediates for their preparation and to their use as herbicides.

SUBSTITUTED THIENE-3-YL-SULFONYL AMINO(THIO)CARBONYL-TRIAZOLIN(THI)ONES

The invention relates to novel substituted thien-3-yl-sulphonylamino(thio)carbonyl-triazolin(ethi)ones of the general formula (I) in which Q1, Q2, R1, R2, R3 and R4 are each as defined in the description, and to salts of the compounds according to formula (I), to processes and to novel intermediates for their preparation and to their use as herbicides.

The Synthesis and Biological Activity of "Crippled Biotin"

(3aα,6β,6aα)-6-Methyltetrahydro-1H-thienopyrrol-2(3H)-one (2) was prepared as a crippled analogue of biotin.The key synthetic step involved hydrogenation of 6-methyl-1H-thienopyrrol-2(3H)-one on palladium to introduce the necessary all-cis configuration.Both compounds were weak inhibitors of the biotin-dependent wheat acetyl-CoA carboxylase compared to substrates or the potent herbicidal inhibitors of this enzyme, but were more potent than biotin or imidazolidone.Neither compound inhibited the biotin-dependent transcarboxylase component of bacterial acetyl-CoA carboxylase, nor did they significantly inhibit the growth of Arabidopsis thaliana.