81534-37-4

Upstream product

• 99-24-1 methyl galloate 
• 1486-47-1 3,4,5-tris(benzyloxy)benzoyl chloride 
• 110850-29-8 methyl 4,6-O-benzylidene-α-D-glucopyranoside 
• 149-91-7 3,4,5-trihydroxybenzoic acid 
• 475161-97-8 benzyl 3,4,5-tris(benzyloxy)benzoate 
• 1486-48-2 3,4,5-tribenzyloxybenzoic acid 
• 2280-44-6 D-Glucose 
• 97-30-3 methyl-alpha-D-glucopyranoside 
• 866330-23-6 methyl 4,6-O-benzylidene-2,3-bis(3-(tert-butyldimethylsiloxy)-4,5-((diphenylmethylene)dioxy)benzoyl)-α-D-glucopyranoside 
• 146322-16-9 tert-butyldimethylsilyl 3-(tert-butyldimethylsilyl)-4,5-(diphenylmethylenedioxy)benzoate 
• 146300-70-1 3-tert-butyldimethylsilyloxy-4,5-(diphenylmethylenedioxy)benzoic acid 
• 69829-46-5 methyl 7-hydroxy-2,2-diphenylbenzo[d]-1,3-dioxole-5-carboxylate 
• 146300-69-8 3,4-(diphenylmethylenedioxy)-5-hydroxybenzoic acid 
• 869278-93-3 methyl 4,6-O-benzylidene-2,3-bis(3,4-((diphenylmethylene)dioxy)-5-hydroxybenzoyl)-α-D-glucopyranoside 

Relevant academic research and scientific papers

The synthesis and antitumor activity of twelve galloyl glucosides

Twelve galloyl glucosides 1-12, showing diverse substitution patterns with two or three galloyl groups, were synthesized using commercially available, low-cost D-glucose and gallic acid as starting materials. Among them, three compounds, methyl 3,6-di-O-galloyl-?±-D-glucopyranoside (9), ethyl 2,3-di-O-galloyl-?±-D-glucopyranoside (11) and ethyl 2,3-di-O-galloyl-?2-D-glucopyranoside (12), are new compounds and other six, 1,6-di-O-galloyl-?2-D-glucopyranose (1), 1,4,6-tri-O-galloyl-?2-D-glucopyranose (2), 1,2-di-O-galloyl-?2-D-glucopyranose (3), 1,3-di-O-galloyl-?2-D-glucopyranose (4), 1,2,3-tri- O-galloyl-?±-D-glucopyranose (6) and methyl 3,4,6-tri-O-galloyl-?±-D-glucopyranoside (10), were synthesized for the first time in the present study. In in vitro MTT assay, 1-12 inhibited human cancer K562, HL-60 and HeLa cells with inhibition rates ranging from 64.2% to 92.9% at 100 ??g/mL, and their IC50 values were determined to be varied in 17.2-124.7 ??M on the tested three human cancer cell lines. In addition, compounds 1-12 inhibited murine sarcoma S180 cells with inhibition rates ranging from 38.7% to 52.8% at 100 ??g/mL in the in vitro MTT assay, and in vivo antitumor activity of 1 and 2 was also detected in murine sarcoma S180 tumor-bearing Kunming mice using taxol as positive control.

Hydrolyzable tannins with the hexahydroxydiphenoyl unit and the m-depsidic link: HPLC-DAD-MS identification and model synthesis

This study was designed to develop efficient analytical tools for the difficult HPLC-DAD-MS identification of hydrolyzable tannins in natural tissue extracts. Throughout the study of the spectroscopic characteristics of properly synthesized stereodefined

O-Methylglucogalloyl esters: Synthesis and evaluation of their antimycotic activity

The two anomers of O-methyl gluco-2,3-digalloyl esters were synthesized and their antimycotic activity toward yeasts of biomedical importance was evaluated. When used at subinhibitory concentration and regardless of stereochemistry at the anomeric carbon,