1486-47-1Relevant articles and documents
Polytopic carriers for platinum ions: From digalloyl depside to tannic acid
Fogagnolo, Marco,Bergamini, Paola,Marchesi, Elena,Marvelli, Lorenza,Gambari, Roberto,Lampronti, Ilaria
, p. 12227 - 12235 (2020)
A novel dinuclear platinum(ii) complex, namely [Pt2m-GG(Me2SO-S)4] (8, GG = deprotonated methyl digallate), was easily synthesized under solvent-free conditions by grinding a solid m/p digalloyl depside with the Pt precursor [PtCO3(Me2SO-S)2]. Similarly, platinum nuclei were introduced into the galloyl chains of tannic acid (TA). In particular, three complexes A, B and C were prepared by reacting TA as a polytopic ligand with an increasing amount of [PtCO3(Me2SO-S)2]. The antiproliferative activity of complexes 8, A, B and C together with the corresponding ligands GG and TA was tested in vitro and compared with that of cisplatin on two human tumor cell lines, A2780 (ovarian cisplatin-sensitive) and A2780cis (ovarian cisplatin-resistant), and one non-tumoral cell line, HaCat. The experiments focusing on their pro-apoptotic activity indicated that the antiproliferative activity of the most active Pt(II) complexes is associated with the induction of apoptosis. This journal is
Synthesis and HIV-1 inhibitory activities of dicaffeoyl and digalloyl esters of quinic acid derivatives
Junior,Verde,Rezende,Caneschi,Couri,McDougall,Robinson Jr.,De Almeida
, p. 724 - 733 (2013)
Twenty analogues of the anti-HIV-1 integrase (IN) inhibitors dicaffeoylquinic acids (DCQAs) were prepared. Their IC50 values for 3'-end processing and strand transfer against recombinant HIV-1IN were determined in vitro, and their cell toxiciti
Hydrolyzable tannins with the hexahydroxydiphenoyl unit and the m-depsidic link: HPLC-DAD-MS identification and model synthesis
Arapitsas, Panagiotis,Menichetti, Stefano,Vincieri, Franco F.,Romani, Annalisa
, p. 48 - 55 (2007)
This study was designed to develop efficient analytical tools for the difficult HPLC-DAD-MS identification of hydrolyzable tannins in natural tissue extracts. Throughout the study of the spectroscopic characteristics of properly synthesized stereodefined
Semisynthetic flavonoid 7-O-galloylquercetin activates Nrf2 and?induces Nrf2-dependent gene expression in RAW264.7 and?Hepa1c1c7 cells
Roubalová, Lenka,Biedermann, David,Papou?ková, Barbora,Vacek, Jan,Kuzma, Marek,K?en, Vladimír,Ulrichová, Jitka,Dinkova-Kostova, Albena T.,Vrba, Ji?í
, p. 58 - 66 (2016)
The natural flavonoid quercetin is known to activate the transcription factor Nrf2, which regulates the expression of cytoprotective enzymes such as heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1). In this study, a novel semisynthetic
Gallic esters of sucrose as efficient radical scavengers in lipid peroxidation
Dufour, Claire,Da Silva, Eric,Potier, Pierre,Queneau, Yves,Dangles, Olivier
, p. 3425 - 3430 (2002)
Three tests of increasing complexity were used to assess the antioxidant activity of five synthetic gallic esters of sucrose bearing 3, 6, 7, or 8 galloyl units. In addition, two of these compounds had 1 or 2 hydrocarbon (C10-C12) acyl chains. Reaction with the DPPH radical led to the evaluation of the number of radicals trapped per galloyl unit n (3-4), as well as the apparent second-order rate constant for H atom donation k (1200-1500/M/s). These results indicated similar contribution and reactivity of all the galloyl units. Inhibition of the AAPH-initiated peroxidation of linoleic acid in a micellar medium confirmed the additive contribution of the galloyl units, whereas the presence of the hydrocarbon acyl chains had no influence. These results suggest an inhibition of initiation at high antioxidant levels and an underlying prooxidant effect of the galloyl radicals at low concentrations. Finally, LDL peroxidation was inhibited in proportion to the number of galloyl units, in agreement with the preceding tests.
Antioxidant cosmetic with allergic skin adaptability
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Paragraph 0023; 0024, (2021/01/28)
According to the invention, N-bis (3, 4, 5-trihydroxybenzoyl) amide and inositol phosphoric acid are subjected to a binding reaction to form an amide salt polyphenol compound of inositol phosphoric acid, and the polyphenol compound maintains excellent ant
Total Synthesis of Macaranin B
Aoyama, Akio,Matsumoto, Shintaro,Wakamori, Shinnosuke,Yamada, Hidetoshi
, p. 1937 - 1944 (2021/09/13)
This study describes the total synthesis of macaranin B, a naturally occurring ellagitannin containing 1-O-galloyl and 3,6-O-macaranoyl groups in an axial-rich d-glucose. The key steps of the synthesis include an oxidative coupling reaction of galloyl gro
INHIBITORS OF ERYTHROCYTE BAND 3 TYROSINE PHOSPHORYLATION AND USES THEREOF
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Page/Page column 40, (2021/01/22)
Inhibitors of erythrocyte band 3 tyrosine phosphorylation, compositions comprising same, and methods of using the inhibitors and compositions to treat sickle cell diseases.
Asymmetric total synthesis of talienbisflavan A
Huang, Deng-Ming,Li, Hui-Jing,Wang, Jun-Hu,Wu, Yan-Chao
supporting information, p. 585 - 592 (2018/02/07)
The first asymmetric total syntheses of talienbisflavan A and bis-8,8′-epicatechinylmethane as well as a facile synthesis of bis-8,8′-catechinylmethane has been accomplished from readily available starting materials by using a newly developed direct regio
N-(3, 4, 5-trihydroxy benzoyl)-3, 4, 5-trihydroxy benzamide and preparation method and application thereof
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Paragraph 0038; 0041; 0044; 0047; 0050; 0052; 0053, (2018/09/14)
The invention discloses N-(3, 4, 5-trihydroxy benzoyl)-3, 4, 5-trihydroxy benzamide and a preparation method and application thereof. The structural formula of the compound is as shown in the description. The compound takes tribenzylgallate as the raw mat
