81535-84-4

Upstream product

• 136590-95-9 [4-(tert-Butyl-dimethyl-silanyloxy)-1-trimethylsilanyloxy-but-2-ynyl]-benzene 
• 6919-61-5 N-methoxy-N-methylbenzamide 
• 76782-82-6 tert-Butyldimethyl(prop-2-ynyloxy)silane 
• 98-88-4 benzoyl chloride 
• 81535-79-7 tert-butyl-dimethyl(3-(tributylstannanyl)prop-2-yn-1-yl)oxysilane 

Downstream Products

• 1360896-22-5 (E)-4-(tert-butyldimethylsilyl)oxy-2-dimethyl(phenyl)silyl-1-phenyl-2-buten-1-one 
• 1207382-05-5 C₁₈H₂₈O₂S₂Si 
• 1207382-10-2 C₁₉H₃₀O₂S₂Si 
• 143878-47-1 4-{[tert-butyl(dimethyl)silyl]oxy}-1-phenylbutan-1-one 

Relevant academic research and scientific papers

INHIBITORS OF HISTONE DEACETYLASE

ABSTRACT OF THE DISCLOSURE This invention relates to compounds and methods for the inhibition of HDAC enzymatic activity. More particularly, the invention provides for compounds of formula (I), (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein L, M, n, R, W, X and Y are as defined in the specification.

MITOTIC KINESIN INHIBITORS

The present invention relates to oxadiazoles that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also relates to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

Room temperature palladium catalysed coupling of acyl chlorides with terminal alkynes

Conditions are reported for the facile, high-yielding coupling of acyl chlorides with terminal alkynes in a reaction involving palladium and copper iodide; the reaction is tolerant of a wide variety of acyl chlorides and terminal alkynes and provides a co

An efficient palladium-catalyzed coupling reaction of lithium alkynyltriisopropoxyborates with acid chlorides: A new access to synthesis of conjugated ynones

An efficient palladium-catalyzed protocol for the synthesis of ynones from lithium alkynyltriisopropoxyborates with acid chlorides under mild neutral conditions.

Highly stereoselective addition of stannylcuprates to alkynones

The addition of stannylcuprate reagents such as (Bu3Sn)(PhS)CuLi to alkynones has been found to proceed in high yield and with excellent stereoselectivity for the Z isomer of the product (>95%). The behavior of the stannylcuprates is thus very different from that of their "carbocuprate" counterparts such as Me2CuLi or Me2Cu(CN)Li2 which are nonstereoselective. Furthermore, in contrast to the reactions of (R3Sn)(PhS)CuLi with the corresponding alkynoates, the presence of a proton source in the reaction medium has no effect on the stereoselectivity of the reaction of alkynones.

Direct oxidation of benzylic and allylic silyl ethers to carbonyl compounds

Oxidation of benzylic or allylic silyl ethers with DDQ under UV irradiation leads directly to the corresponding carbonyl compounds with moderate to good yields.

Palladium-Catalyzed Reactions of Acyl Chlorides with (1-Alkynyl)tributylstannanes. A Convenient Synthesis for 1-Alkynyl Ketones

Acyl chlorides couple with (1-alkynyl)tributylstannanes in the presence of catalytic amounts of palladium(II) or palladium(0) complexes to produce 1-alkynyl ketones in respectable yields.The couplings of isobutyryl, acetyl, benzoyl, and p-nitrobenzoyl chlorides with phenylethynyl-, (trimethylsilyl)ethynyl-, (carbomethoxy)ethynyl-, -1-propynyl>-, and (3,3-diethoxy-1-propynyl)tributylstannanes were investigated in the presence of tetrakis(triphenylphosphine)palladium(O), benzylchlorobis(triphenylphosphine)palladium(II), dichlorobis(triphenylphosphine)palladium(II), or phenyliodobis(triphenylphosphine)palladium(II).The reactions are highly selective in that only the alkynyl groups are transferred from the stannane.