81536-10-9Relevant academic research and scientific papers
Base-Promoted Oxidative C(sp3)–S Bond Cross-Coupling of Inactive Fluorenes and Thiols for the Synthesis of 9-Monothiolated Fluorenes
Liu, Yafeng,Yuan, Xinglong,Su, Kexin,Tian, Yuan,Chen, Baohua
, p. 1649 - 1652 (2019)
The highly efficient and selective C(sp3)–S bond cross-coupling method for the synthesis of 9-thiolated fluorenes through a direct thiolation at 9-C(sp3)–H of fluorenes with thiols is described. This reaction occurs at ambient conditions and shows good tolerance of functional groups including arylthiols and alkylthiols. A wide range of products is obtained in moderate to good yields. Besides, the reaction of benzothiophenol and fluorine generates unexpected 9-benzylidene-9H-fluorene by eliminating hydrogen sulfide.
